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Acts as a ventralizing factor during embryogenesis. Additionally we are shipping Axin Interactor, Dorsalization Associated Proteins (8) and Axin Interactor, Dorsalization Associated Kits (2) and many more products for this protein.
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A dorsalization (show AXIN1 Antibodies)pathway that (show MAPK8 Antibodies)is exerted by Axin/JNK signali (show AXIN1 Antibodies)ng and its inhibitor Aida during vertebrate embryogenesis, is defined.
Aida blocks Axin (show AXIN1 Antibodies)-mediated JNK (show MAPK8 Antibodies) activation by disrupting Axin (show AXIN1 Antibodies) homodimerization. In zebrafish embryos, the dorsalization induced by axin (show AXIN1 Antibodies) could be repressed by aida. This activity of aida is conferred by its ability to block Axin (show AXIN1 Antibodies)-mediated JNK (show MAPK8 Antibodies) activity.
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).
chromosome 1 open reading frame 80
, axin interactor, dorsalization-associated protein
, UPF0491 protein C1orf80 homolog
, axin interaction partner and dorsalization antagonist