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BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) ELISA Kits

The protein encoded by BIK shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Additionally we are shipping BIK Antibodies (124) and BIK Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse BIK BIK 12124  
BIK 638 Q13323
Anti-Rat BIK BIK 114496  
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Top BIK ELISA Kits at antibodies-online.com

Showing 1 out of 5 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 2 to 3 Days
$480.00
Details

More ELISA Kits for BIK Interaction Partners

Mouse (Murine) BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 ELISA Kits) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  2. Src (show SRC ELISA Kits) tyrosine kinase (show TYRO3 ELISA Kits) inhibits apoptosis through the Erk1/2 (show MAPK1/3 ELISA Kits)- dependent degradation of the death accelerator Bik.

  3. The Bik protein, even in combination with Noxa (show PMAIP1 ELISA Kits), is not a potent suppressor of c-Myc (show MYC ELISA Kits)-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc (show MYC ELISA Kits)-driven tumours.

  4. BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib.

  5. Blk has been mapped to chromosome 15 and overexpressed in transitional B cells of A/WySnJ mice, which demonstrate a cell-autonomous defect leading to excessive apoptosis.

  6. any function of Bik in programmed cell death and stress-induced apoptosis must overlap that of other BH3-only (show BBC3 ELISA Kits) proteins

  7. Data show that Bik and Bim (show BCL2L11 ELISA Kits) share the role of eliminating supernumerary germ cells during the first wave of spermatogenesis, a process vital for normal testicular development.

  8. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR (show CCKAR ELISA Kits)-VISA (show MAVS ELISA Kits), exhibited antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic mouse models of pancreatic tumors with virtually no toxicity

  9. evaluated the inhibitory effect of BikDD on the growth kinetics of intraperitoneally inoculated CT-26-Luc

  10. Enhanced expression in Bcl-2 (show BCL2 ELISA Kits) deficient cells leads to cell death with autophagic features.

Human BCL2-Interacting Killer (Apoptosis-Inducing) (BIK) interaction partners

  1. our data demonstrated that suppression of BIK in ER-positive MCF-7 cells prevents the cytotoxic effect of TAM (show CCNA1 ELISA Kits) and favors a more aggressive phenotype, due to the molecular change of different pathways

  2. HCV RNA replication and release were significantly suppressed in BIK-depleted cells and over-expression of the RNA-dependent RNA polymerase, NS5B, was able to induce BIK expression

  3. BikDDA, a novel mutant of Bik, showed a prolonged half-life and enhanced pro-apoptotic ability in triple-negative breast cancer cells compared with BikDD.

  4. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 (show SQSTM1 ELISA Kits) converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.

  5. Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.

  6. Data suggest BIK expression in tumor cells is not subject to direct regulation by MAP kinase (show MAPK1 ELISA Kits) signaling; BIK expression appears to be cell-cycle-dependent and increases in G1 cell-cycle arrest which results from inhibition of MAP kinase (show MAPK1 ELISA Kits) signaling.

  7. BIK/NBK gene expression may have important clinical implications and provide predictive, prognostic or therapeutic marker in breast cancer patients

  8. Src (show SRC ELISA Kits) tyrosine kinase (show TXK ELISA Kits) inhibits apoptosis through the Erk1/2 (show MAPK1/3 ELISA Kits)- dependent degradation of the death accelerator Bik.

  9. A previously undescribed indirect epigenetic regulation of BIK in FA-C lymphoblasts is mediated by DeltaNp73, an isoform of p73 (show TP73 ELISA Kits) lacking its transactivation domain that activates BIK through a proximal element in its promoter.

  10. Data indicate that methylation-induced transcriptional silencing of the BIK (bcl2-interacting killer) pro-apoptotic gene may occur in multiple myeloma (MM), which might serve as a predictor of the development of relapsed/refractory MM.

BIK Antigen Profile

Antigen Summary

The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.

Gene names and symbols associated with BIK

  • BCL2-interacting killer (apoptosis-inducing) (BIK) antibody
  • BCL2-interacting killer (BIK) antibody
  • BCL2-interacting killer (Bik) antibody
  • BCL2-interacting killer (apoptosis-inducing) (Bik) antibody
  • BCL2-interacting killer (apoptosis-inducing) (bik) antibody
  • BIK antibody
  • Biklk antibody
  • BIP1 antibody
  • Blk antibody
  • BP4 antibody
  • NBK antibody
  • si:dkey-31f5.6 antibody

Protein level used designations for BIK

BCL2-interacting killer (apoptosis-inducing) , BCL2-interacting killer , apoptosis inducer NBK , bcl-2-interacting killer , bik-like killer protein , apoptosis-inducing NBK

GENE ID SPECIES
470232 Pan troglodytes
711479 Macaca mulatta
790946 Felis catus
12124 Mus musculus
638 Homo sapiens
114496 Rattus norvegicus
564030 Danio rerio
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