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BCL2L2 encodes a member of the BCL-2 protein family. Additionally we are shipping BCL2-Like 2 Antibodies (113) and BCL2-Like 2 Kits (7) and many more products for this protein.
Showing 10 out of 21 products:
Human BCL2L2 Protein expressed in Escherichia coli (E. coli) - ABIN666929
Kroemer: The proto-oncogene Bcl-2 and its role in regulating apoptosis. in Nature medicine 1997
Show all 2 references for ABIN666929
Genetic and pharmacological inhibition of BCL-W and BCL-XL (show BCL2L1 Proteins) causes directed elimination of senescent cells.
Data show that BCL2-like 2 protein (BCL2L2) is a direct target of micrRNA miR (show MLXIP Proteins)-29b.
these results indicate that miR (show MLXIP Proteins)-335 acts as a novel tumor suppressor to regulate ccRCC cell proliferation and invasion through downregulation of BCL-W expression.
miR (show MLXIP Proteins)-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC.
The crystal structures of BCL-W and BCL-XL (show BCL2L1 Proteins), along with cellular, studies reveal critical features of the BH3 domains of pro-survival proteins that distinguish them functionally from their pro-apoptotic counterparts.
over-expression of miR (show MLXIP Proteins)-195 sensitized resistant cells to DOX and enhanced cell apoptosis activity, all of which can be partly rescued by BCL2L2 siRNA and cDNA expression
A structural basis for a conserved binding mechanism between p53DBD and the anti-apoptotic Bcl-2 (show BCL2 Proteins) family proteins.
Bcl-w-induced Sp1 (show PSG1 Proteins) activation is a potential marker for aggressiveness of glioblastoma multiforme.
HDMF inhibits Bcl-w-induced neurosphere formation and the expression of glioma stem cell markers, such as Musashi (show MSI1 Proteins), Sox-2 (show SOX2 Proteins) and c-myc (show MYC Proteins).
Crystal structure of human BCL-W in complex with different DARPins is virtually identical to the ligand-free conformation of its closest relative BCL-XL (show BCL2L1 Proteins).
NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins)/p52 (show GTF2H4 Proteins) signaling mediated the effects of GDNF (show GDNF Proteins) on Bcl-2 (show BCL2 Proteins) and Bcl-w expressions
Target-derived neurotrophins coordinate transcription of the antiapoptotic gene bclw with transport of bclw mRNA to the axon, and thereby prevent axonal degeneration in rat and mouse sensory neurons.
By using human cancer cells and mouse embryonic fibroblasts, the study shows that Bcl-w functions in the mitochondria to increase the levels of reactive oxygen species (ROS (show ROS1 Proteins)), which subsequently stimulates the invasion-promoting signaling pathway.
Bcl-2 (show BCL2 Proteins), Bcl-x(L (show BCL2L1 Proteins)) and Bcl-w have only minor roles in thymic lymphoma development elicited by defects in p53 (show TP53 Proteins), and this may indicate that Mcl-1 (show MCL1 Proteins) and/or A1 may feature more prominently in this process.
Induction of autocrine Bcl-w signaling through pericytes promoting endothelial cell survival is associated with melanoma development.
Bcl-w(-/-) sensory neurons exhibit mitochondrial abnormalities, including alterations in axonal mitochondrial size, axonal mitochondrial membrane potential, and cellular ATP levels.
Bcl-x(L) and Bcl-w target protein phosphatase 1alpha to Bad
Bcl-2 (show BCL2 Proteins), Bcl-w, and Bax (show BAX Proteins) act in a redundant manner in regulating granulocyte survival and death
amino acid and base sequences of c98 gene (bcl-2 (show BCL2 Proteins) homolog) expressed in newborn epidermal keratinocytes treated with IGF-1 (show IGF1 Proteins)
Chromosome mapping of BCL2L2 gene in cows.
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
, BCL2-like 2
, apoptosis regulator BCL-W
, bcl-2-like protein 2
, protein phosphatase 1, regulatory subunit 51
, apoptosis regulator Bcl-W