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BCL2L2 encodes a member of the BCL-2 protein family. Additionally we are shipping BCL2-Like 2 Proteins (20) and BCL2-Like 2 Kits (11) and many more products for this protein.
Showing 10 out of 122 products:
Human Monoclonal BCL2L2 Primary Antibody for WB - ABIN967292
Adams, Cory: The Bcl-2 protein family: arbiters of cell survival. in Science (New York, N.Y.) 1998
Show all 5 Pubmed References
High expression of Bcl-w was associated with mesenchymal changes and invading populations in the glioblastoma multiforme; Bcl-w functions as a positive regulator of invasion by enhancing mesenchymal traits of glioblastoma multiforme, consequently contributing to malignancy.
BCL2L2 was the virtual target of miR (show MLXIP Antibodies)-133b, and we found a negative regulatory relationship between miR (show MLXIP Antibodies)-133b and BCL2L2. MiR (show MLXIP Antibodies)-133b and BCL2L2 interfered with the viability and apoptosis of cells.
overexpression of miR (show MLXIP Antibodies)-15a in the FaDu cells was associated with significantly decreased BCL2L2 and BCL2 (show BCL2 Antibodies) expression and a significant increase in the apoptosis rate. The opposite results were observed in HPV-positive HSCC, where downregulation of miR (show MLXIP Antibodies)-15a suppressed apoptosis
we conclude that BER treatment reduces cisplatin resistance of gastric cancer cells by modulating the miR (show MLXIP Antibodies)-203/Bcl-w apoptotic axis. BER may be a novel agent to enhance chemotherapeutic responses in cisplatin-resistant gastric cancer patients
Genetic and pharmacological inhibition of BCL-W and BCL-XL (show BCL2L1 Antibodies) causes directed elimination of senescent cells.
Data show that BCL2-like 2 protein (BCL2L2) is a direct target of micrRNA miR (show MLXIP Antibodies)-29b.
these results indicate that miR (show MLXIP Antibodies)-335 acts as a novel tumor suppressor to regulate ccRCC cell proliferation and invasion through downregulation of BCL-W expression.
miR (show MLXIP Antibodies)-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC.
The crystal structures of BCL-W and BCL-XL (show BCL2L1 Antibodies), along with cellular, studies reveal critical features of the BH3 domains of pro-survival proteins that distinguish them functionally from their pro-apoptotic counterparts.
over-expression of miR (show MLXIP Antibodies)-195 sensitized resistant cells to DOX and enhanced cell apoptosis activity, all of which can be partly rescued by BCL2L2 siRNA and cDNA expression
MYC (show MYC Antibodies) regulates BCL-W expression through its transcriptional regulation of specific miR (show MLXIP Antibodies).
NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies)/p52 (show GTF2H4 Antibodies) signaling mediated the effects of GDNF on Bcl-2 (show BCL2 Antibodies) and Bcl-w expressions
Target-derived neurotrophins coordinate transcription of the antiapoptotic gene bclw with transport of bclw mRNA to the axon, and thereby prevent axonal degeneration in rat and mouse sensory neurons.
By using human cancer cells and mouse embryonic fibroblasts, the study shows that Bcl-w functions in the mitochondria to increase the levels of reactive oxygen species (ROS (show ROS1 Antibodies)), which subsequently stimulates the invasion-promoting signaling pathway.
Bcl-2 (show BCL2 Antibodies), Bcl-x(L (show BCL2L1 Antibodies)) and Bcl-w have only minor roles in thymic lymphoma development elicited by defects in p53 (show TP53 Antibodies), and this may indicate that Mcl-1 (show MCL1 Antibodies) and/or A1 may feature more prominently in this process.
Induction of autocrine Bcl-w signaling through pericytes promoting endothelial cell survival is associated with melanoma development.
Bcl-w(-/-) sensory neurons exhibit mitochondrial abnormalities, including alterations in axonal mitochondrial size, axonal mitochondrial membrane potential, and cellular ATP levels.
Bcl-x(L) and Bcl-w target protein phosphatase 1alpha to Bad
Bcl-2 (show BCL2 Antibodies), Bcl-w, and Bax (show BAX Antibodies) act in a redundant manner in regulating granulocyte survival and death
Chromosome mapping of BCL2L2 gene in cows.
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
, BCL2-like 2
, apoptosis regulator BCL-W
, bcl-2-like protein 2
, protein phosphatase 1, regulatory subunit 51
, apoptosis regulator Bcl-W