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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. Additionally we are shipping BCOR Antibodies (57) and BCOR Kits (2) and many more products for this protein.
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we report recurrent BCOR exon 16 internal tandem duplications and YWHAE (show YWHAE Proteins)-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
All small blue round cell tumors (SBRCTs) with BCOR-MAML3 and BCOR-CCNB3 (show CCNB3 Proteins) fusions, as well as most with BCOR internal tandem duplications (93%), and all clear cell sarcoma of kidney showed strong and diffuse nuclear BCOR immunoreactivity.
we find that ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade endometrial stromal sarcoma and shares significant morphologic overlap with myxoid leiomyosarcoma
We report the case of a 7-month-old girl with atypical oculo-facio-cardio-dental syndrome (OFCD). A novel de novo pathogenic mutation in the BCL6 (show BCL6 Proteins) interacting co-repressor gene (BCOR) (c.4540C>T; p.Arg1514*), was identified on the X chromosome
ZC3H7B-BCOR and MEAF6 (show MEAF6 Proteins)-PHF1 (show PHF1 Proteins) fusions occurred predominantly in S100 protein-negative and malignant OFMT.
Given the high frequency and pattern of aberration, BCOR is likely to play an important role in ENKTL pathogenesis as a tumor suppressor gene
Data suggest the detection of the partial duplication inside exon 15 of proto-oncogene (show RAB1A Proteins) protein BCOR as part of the diagnostic process of pediatric kidney tumors.
Report mutually exclusive BCOR internal tandem duplications and YWHAE (show YWHAE Proteins)-NUTM2 fusions in clear cell sarcoma of kidney.
The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 and ZC3H7B-BCOR, identified
Somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR were found in 85% of pediatric clear cell sarcoma of the kidney. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours.
results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (show IRF8 Proteins) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B (show KDM2B Proteins) complex by Study using a high throughput proteomics approach identified interactors with Rnf2 (show RNF2 Proteins) including Fbxl10/Jhdm1B (show KDM2B Proteins), casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL6 co-repressor
, BCL-6 interacting corepressor
, Bcl6 interacting corepressor