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The protein encoded by BCOR was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. Additionally we are shipping BCOR Antibodies (59) and BCOR Kits (2) and many more products for this protein.
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Given the high frequency and pattern of aberration, BCOR is likely to play an important role in ENKTL pathogenesis as a tumor suppressor gene
Data suggest the detection of the partial duplication inside exon 15 of proto-oncogene (show RAB1A Proteins) protein BCOR as part of the diagnostic process of pediatric kidney tumors.
Report mutually exclusive BCOR internal tandem duplications and YWHAE (show YWHAE Proteins)-NUTM2 fusions in clear cell sarcoma of kidney.
The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 and ZC3H7B-BCOR, identified
Somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR were found in 85% of pediatric clear cell sarcoma of the kidney. Mutant BCOR transcripts and proteins are markedly upregulated in ITD-positive tumours.
This study adds to recent reports on the clinicopathologic spectrum of BCOR-CCNB3 (show CCNB3 Proteins) fusion-positive sarcomas, a newly emerging entity within the undifferentiated unclassified sarcoma category
Using reported human BCOR mutations in patients with oculofaciocardiodental syndrome, the authors identified nuclear localization signals at two possible sites; at aa1131-1141 (NLS1) and at aa1158-1167(NLS2).
study concluded that in pediatric acute myeloid leukemia, BCOR and BCORL1 mutations rarely occur
Data indicate that the internal tandem duplications in the BCOR gene (BCL6 corepressor) affecting the C terminus in 100% (20/20) of clear cell sarcoma of the kidney (CCSK) tumors
report of the clinical and molecular data of 3 new patients with oculofaciocardiodenta and review the literature for all published patients and their mutations in the BCOR gene
Data show that BCL6 interacting corepressor Bcor Is Specifically Down-regulated by Activin Signaling in trophoblast stem cells (TSCs).
T cell-expressed BCOR is critical for optimal GC-Tfh cell differentiation and humoral immunity.
IRF8 (show IRF8 Proteins) pairs with BCL6 co-repressor BCOR in the nucleus to enhance its transcriptional repressive activity.
Results suggest that Bcor expressed in the mesenchyme plays crucial roles during early tooth development.
Study isolated an Fbxl10/Jhdm1B (show KDM2B Proteins) complex by Study using a high throughput proteomics approach identified interactors with Rnf2 (show RNF2 Proteins) including Fbxl10/Jhdm1B (show KDM2B Proteins), casein kinase subunits, and the BcoR corepressor
Bcor plays a role in differentiation of multiple tissue lineages during early embryonic development.
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.
, BCL6 co-repressor
, BCL-6 interacting corepressor
, Bcl6 interacting corepressor