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BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) Proteins (BRF1)

BRF1 encodes one of the three subunits of the RNA polymerase III transcription factor complex. Additionally we are shipping BRF1 Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRF1 72308  
BRF1 2972 Q92994
Rat BRF1 BRF1 299347  
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Top BRF1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

BRF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) Interaction Partners

Fruit Fly (Drosophila melanogaster) BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) interaction partners

  1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription

Mouse (Murine) BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) interaction partners

  1. Brf1 (zfp36l1 (show ZFP36L1 Proteins)), an AU-rich element mRNA-binding protein from the Zfp36 (show ZFP36 Proteins) protein family, operates downstream of FGF/Erk MAP kinase (show MAPK1 Proteins) signaling to regulate pluripotency and cell fate decision making in mouse embryonic stem cells.

  2. Alcohol induces RNA polymerase III-dependent transcription through c-Jun (show JUN Proteins) by co-regulating TATA-binding protein (TBP (show TBP Proteins)) and Brf1 (show ZFP36L1 Proteins) expression.

  3. Phosphorylation at serine-92 and serine-203 is involved in BRF1 protein stability; high BRF1 protein levels are required to reinstate decay upon dissipation of the stabilizing signal.

Human BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) (BRF1) interaction partners

  1. BRF1 mutations that reduce protein activity cause neurodevelopmental anomalies, suggesting that BRF1-mediated Pol III transcription is required for normal cerebellar and cognitive development.

  2. hnRNP F (show HNRNPF Proteins) is a co-factor in a subset of tristetraprolin (show ZFP36 Proteins)/BRF1 (show ZFP36L1 Proteins)/BRF2 (show ZFP36L2 Proteins)-mediated mRNA decay.

  3. these observations are in favor of a cell- and context-dependent regulation of Tis11b (show ZFP36L1 Proteins) by hypoxia, which then contributes to modulation of angiogenesis.

  4. Alcohol induces RNA polymerase III-dependent transcription through c-Jun (show JUN Proteins) by co-regulating TATA-binding protein (TBP (show TBP Proteins)) and Brf1 (show ZFP36L1 Proteins) expression.

  5. results identify a human Pol III isoform and isoform-specific functions in the regulation of cell growth and transformation

  6. CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells.

  7. BRF1 accelerated mRNA decay and antagonized the stabilizing effect of PI3-kinase, while mutation of the zinc fingers abolished both function and ARE-binding activity. This approach identifies BRF1 as an essential regulator of ARE-dependent mRNA decay.

  8. Data report that protein kinase B (PKB/Akt (show AKT1 Proteins)) stabilizes ARE transcripts by phosphorylating butyrate response factor (BRF1 (show ZFP36L1 Proteins)) at serine 92.

  9. These results suggest a direct role of an RNA polymerase III transcription factor in the targeting process.

  10. depletion of endogenous TTP (show ADAMTS13 Proteins) and BRF-1 (show ZFP36L1 Proteins) proteins, or overexpression of dominant-negative mutant TTP (show ADAMTS13 Proteins) proteins, impairs the localization of reporter AU-rich element mRNAs

BRF1 Protein Profile

Protein Summary

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified.

Gene names and symbols associated with BRF1

  • CG31256 gene product from transcript CG31256-RA (Brf)
  • zgc:73380 (zgc:73380)
  • general transcription factor IIB (GTF2B)
  • transcription factor iib (PFE0415w)
  • transcription factor IIB (Tb09.160.4220)
  • transcription factor IIb (PVX_097980)
  • transcription factor IIB (CpipJ_CPIJ011738)
  • transcription factor IIB (CpipJ_CPIJ014799)
  • transcription factor IIB (CpipJ_CPIJ018710)
  • Transcription factor iib (PKH_102450)
  • transcription initiation factor IIB (gtf2b)
  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (BRF1)
  • BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) (Brf1)
  • BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit (BRF1)
  • BRF1, RNA polymerase III transcription initiation factor 90 subunit (Brf1)
  • 2510002F24Rik protein
  • brf protein
  • BRF-1 protein
  • BRF1 protein
  • CG4155 protein
  • CG5419 protein
  • CG31256 protein
  • DDBDRAFT_0189159 protein
  • DDBDRAFT_0216283 protein
  • DDB_0189159 protein
  • DDB_0216283 protein
  • Dmel\\CG31256 protein
  • GTF2B protein
  • GTF3B protein
  • hBRF protein
  • mTFIIIB90 protein
  • TAF3B2 protein
  • TAF3C protein
  • TAFIII90 protein
  • TF3B90 protein
  • TFIIIB protein
  • TFIIIB90 protein
  • ZFP36L1 protein

Protein level used designations for BRF1

Brf-PA , Brf-PB , CG31256-PA , CG31256-PB , RNA Pol III transcription factor , UPF0468 protein C16orf80 homolog , transcription initiation factor IIB , general transcription factor IIB , transcription factor iib , transcription factor IIB , transcription factor IIb , Transcription factor iib , general transcription factor TFIIB , BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) , transcription initiation factor IIIB , zinc finger protein 36, C3H type-like 1 , B-related factor 1 , BRF-1 , hTFIIIB90 , transcription factor IIIB 90 kDa subunit , B - related factor 1 , BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB , TATA box binding protein (TBP)-associated factor 3C , TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2 , TBP - associated factor, RNA polymerase III, 90kD , general transcription factor IIIB, 90kD subunit

GENE ID SPECIES
42087 Drosophila melanogaster
393784 Danio rerio
694770 Macaca mulatta
743356 Pan troglodytes
812860 Plasmodium falciparum 3D7
3660552 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5472512 Plasmodium vivax Sal-1
6044607 Culex quinquefasciatus
6048330 Culex quinquefasciatus
6052828 Culex quinquefasciatus
7321100 Plasmodium knowlesi strain H
8627902 Dictyostelium discoideum AX4
100173138 Pongo abelii
423503 Gallus gallus
453212 Pan troglodytes
490883 Canis lupus familiaris
72308 Mus musculus
2972 Homo sapiens
299347 Rattus norvegicus
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