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Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Antibodies (74) and many more products for this protein.
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Results suggest that the mTOR (show FRAP1 Proteins)-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement.
The Bach2-C/EBPbeta (show CEBPB Proteins) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data (including data from studies using transgenic/knockout mice) suggest that hyperactivated T-lymphocytes induce specific gene expression patterns in alveolar macrophages and dendritic cells; pulmonary alveolar proteinosis phenotype of Bach2-deficient mice is due to Bach2 deficiency in at least two types of immune cells, alveolar macrophages and dendritic cells.
Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB (show NFKB1 Proteins) subunit proto-oncogene (show RAB1A Proteins) protein c (show PROC Proteins)-rel (c-Rel (show NFkBP65 Proteins)) .
In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.
this study shows that the transcription factor BACH2 promotes memory CD8 (show CD8A Proteins)+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 (show JUN Proteins)
this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells
Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 (show IL5 Proteins) in CD4 (show CD4 Proteins)(+) T cells.
These results suggest that Bach1 (show BACH1 Proteins) and Bach2 work in a complementary manner to maintain the normal function of the AMs (show MAT1A Proteins) and surfactant homeostasis in the lung.
these data also showed that mouse Bach2 mRNA was a novel target of miR (show MLXIP Proteins)-30b.
Data show that BACH2 and STAT5B (show STAT5B Proteins) are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence.
BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.
BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (show HELLS Proteins) consisting of deactivated Cas9 (dCas9) nuclease (show DCLRE1C Proteins) and catalytic domain of the DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (show HELLS Proteins) of a wider promoter region of the target loci IL6ST (show IL6ST Proteins) and BACH2 decreased their expression
genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.
The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.
The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.
The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.
Gene expression analysis revealed that three gene BACH2, PTGER4 (show PTGER4 Proteins) and ZFP36L1 (show ZFP36L1 Proteins), are down-regulated in MS patients' blood cells compared to healthy subjects.
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).
BTB and CNC homolog 2
, Transcription regulator protein BACH2 (BTB and CNC homolog 2)
, transcription regulator protein BACH2
, BTB and CNC homology 2
, BTB and CNC homology 1, basic leucine zipper transcription factor 2
, transcription regulator protein BACH2-like