BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 Proteins (BACH2)

Transcriptional regulator that acts as repressor or activator. Additionally we are shipping BACH2 Antibodies (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BACH2 12014  
Rat BACH2 BACH2 313125  
BACH2 60468 Q9BYV9
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Top BACH2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$293.51
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BACH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) Interaction Partners

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. BACH2 downregulation contributes to constitutive activation of the nuclear factor-kappaB.

  2. BACH2 haploinsufficiency causing a syndrome of immune deficiency and autoimmunity is described in two families. Affected subjects had lymphocyte-maturation defects that caused immunoglobulin deficiency and intestinal inflammation.

  3. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  4. we developed a CRISPR-Cas9-based tool for specific DNA methylation (show HELLS Proteins) consisting of deactivated Cas9 (dCas9) nuclease (show DCLRE1C Proteins) and catalytic domain of the DNA methyltransferase (show DNMT1 Proteins) DNMT3A (show DNMT3A Proteins) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (show HELLS Proteins) of a wider promoter region of the target loci IL6ST (show IL6ST Proteins) and BACH2 decreased their expression

  5. genetic association studies in population in the United Kingdom: Data suggest that an SNP in BACH2 (rs3757247) is associated with autoimmune Addison's disease and with polyglandular autoimmune syndrome type 2. These findings were replicated in a Norwegian validation cohort.

  6. The shift in the CSDs by heme binding suggested that heme binding causes Bach2(331-520) to adopt a more compact conformation. In addition, heme binding to the CP-motif could reduce the flexibility of Bach2(331-520) Consequently, the five-coordinated heme binding destabilizes Bach2(331-520), by reducing the flexibility of the polypeptide chain.

  7. The study identifies a strong association of Coeliac Disease with a network of BACH2 regulated genes, supporting emerging evidence of an important role of BACH2 in the regulation of T cell differentiation and prevention of autoimmune disease.

  8. The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either Vogt-Koyanagi-Harada syndrome and Behcet's disease in our investigated Chinese Han population.

  9. Gene expression analysis revealed that three gene BACH2, PTGER4 (show PTGER4 Proteins) and ZFP36L1 (show ZFP36L1 Proteins), are down-regulated in MS patients' blood cells compared to healthy subjects.

  10. These observations suggested that the unstructured region of Bach2 is important for heme binding, and consequently for its functional regulation

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 2 (BACH2) interaction partners

  1. Data show that B-cell tumour suppressor BTB and CNC homology 2 (Bach2) was significantly downregulated by the loss of NF-kappaB (show NFKB1 Proteins) subunit proto-oncogene (show RAB1A Proteins) protein c (show PROC Proteins)-rel (c-Rel (show NFkBP65 Proteins)) .

  2. In this study silencing BACH2 in mantle cell lymphoma cells resulted in increased proliferation and enhanced tumor dispersal in hypoxic microenvironments, suggesting a tumor suppressor-like role of BACH2.

  3. this study shows that the transcription factor BACH2 promotes memory CD8 (show CD8A Proteins)+ T cell generation by blocking access to genomic regulatory sites recognized by AP-1 (show JUN Proteins)

  4. this study shows that B cells of lower affinity receive weaker T cell help, which results in higher expression of the transcriptional repressor Bach2 and promotes the development of memory B cells

  5. Bach2 controls homeostasis of eosinophils via restricting the production of Il-5 (show IL5 Proteins) in CD4 (show CD4 Proteins)(+) T cells.

  6. These results suggest that Bach1 (show BACH1 Proteins) and Bach2 work in a complementary manner to maintain the normal function of the AMs (show MAT1A Proteins) and surfactant homeostasis in the lung.

  7. these data also showed that mouse Bach2 mRNA was a novel target of miR (show MLXIP Proteins)-30b.

  8. PI3K-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway inhibits Bach2 by both repressing its expression and inducing its phosphorylation in B cells.

  9. Bach2 is suggested to cooperate with HDAC3 (show HDAC3 Proteins)-containing co-repressor complexes in B cells to regulate the stage-specific expression of Prdm1 (show PRDM1 Proteins) by writing epigenetic modifications at the Prdm1 (show PRDM1 Proteins) locus.

  10. These findings demonstrate that BACH2 is a key component of the molecular program of tumor immunosuppression and identify therapeutic targets for the reversal of immunosuppression in cancer.

BACH2 Protein Profile

Protein Summary

Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).

Gene names and symbols associated with BACH2

  • BTB and CNC homology, basic leucine zipper transcription factor 2 (Bach2)
  • BTB domain and CNC homolog 2 (Bach2)
  • BTB domain and CNC homolog 2 (BACH2)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 2b (bach2b)
  • BTB domain and CNC homolog 2 (bach2)
  • bach2 protein
  • BTBD25 protein
  • E030004N02Rik protein
  • si:dkeyp-4f12.1 protein
  • si:dkeyp-4f12.2 protein

Protein level used designations for BACH2

BTB and CNC homolog 2 , Transcription regulator protein BACH2 (BTB and CNC homolog 2) , transcription regulator protein BACH2 , BTB and CNC homology 2 , BTB and CNC homology 1, basic leucine zipper transcription factor 2 , transcription regulator protein BACH2-like

GENE ID SPECIES
12014 Mus musculus
313125 Rattus norvegicus
60468 Homo sapiens
421809 Gallus gallus
481923 Canis lupus familiaris
538296 Bos taurus
555350 Danio rerio
702740 Macaca mulatta
100065814 Equus caballus
100218595 Taeniopygia guttata
100351257 Oryctolagus cuniculus
100402816 Callithrix jacchus
100447938 Pongo abelii
100467178 Ailuropoda melanoleuca
100485849 Xenopus (Silurana) tropicalis
100025933 Monodelphis domestica
100554926 Anolis carolinensis
100595920 Nomascus leucogenys
100717541 Cavia porcellus
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