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Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).. Additionally we are shipping BOD1 Antibodies (53) and BOD1 Kits (3) and many more products for this protein.
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we established two Drosophila models, where neuron-specific knockdown of BOD1 caused pronounced learning deficits and significant abnormalities in synapse morphology. Together our results reveal novel postmitotic functions of BOD1 as well as pathogenic mechanisms that strongly support a causative role of BOD1 deficiency in the aetiology of intellectual disability.
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
siRNA depeletion of Fam44B (named Bod1 - Biorientation Defective 1 in this publication) resulted in persistent chromosome congression defects in metaphase.
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles (By similarity).
biorientation defective 1
, biorientation of chromosomes in cell division protein 1
, family with sequence similarity 44, member B
, biorientation defective protein 1
, bone length and organs 1