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Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) Proteins (BRE)

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Additionally we are shipping BRE Antibodies (62) and BRE Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRE 9577 Q9NXR7
BRE 362704 Q6P7Q1
BRE 107976 Q8K3W0
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Top BRE Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Branchiostoma floridae His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Saguinus oedipus His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
Yeast REACT_Green monkey His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details

BRE Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) Interaction Partners

Human Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) interaction partners

  1. High BRE and high EVI1 (show MECOM Proteins) expression are mutually exclusive in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins)-positive acute myeloid leukemia (show BCL11A Proteins) patients.

  2. High BRE expression defines a novel subtype of adult acute myeloid leukemia (show BCL11A Proteins) characterized by a favorable prognosis.

  3. NBA1/MERIT40 (show BABAM1 Proteins) and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36 (show BRCC3 Proteins)-containing complexes

  4. overexpression of the BRE gene is predominantly found in MLL (show MLL Proteins)-rearranged AML (show RUNX1 Proteins) with t(9;11)(p22 (show DYNC1H1 Proteins);q23).

  5. A novel stress-responsive gene called BRE which interacts with TNF (show TNF Proteins)-receptor-1 and blocks the apoptotic effect of TNF-alpha (show TNF Proteins), was identified.

  6. These results show that BRE over-expression can indeed promote growth, though not initiation, of liver tumors.

  7. BRE mediates antiapoptosis by inhibiting the mitochondrial apoptotic machinery

  8. the enhanced tumor growth is more likely due to the antiapoptotic activity of BRE than any direct effect of the protein on cell proliferation

  9. Antiapoptotic in vivo; Bre levels are regulated post-transcriptionally in the liver, which is not observed in human hepatocellular carcinoma (HCC (show FAM126A Proteins)) and non-HCC (show FAM126A Proteins) cell lines.

  10. results implied that BRE plays a significant role in mediating antiapoptotic and proliferative responses in esophageal carcinoma cells

Mouse (Murine) Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) interaction partners

  1. Depletion of BRE also increased tumor cell apoptosis, and decreased both local and metastatic tumor growth.

  2. BRE has a role in the regulation of key proteins of the cellular stress-response machinery, including prohibitin (show PHB Proteins) and p53 (show TP53 Proteins)

BRE Protein Profile

Protein Summary

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).

Gene names and symbols associated with BRE

  • brain and reproductive organ-expressed (TNFRSF1A modulator) (bre)
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE)
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (LOC100231620)
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (LOC100347469)
  • brain and reproductive organ-expressed (TNFRSF1A modulator) (Bre)
  • brain and reproductive organ-expressed protein (Bre)
  • brain and reproductive organ-expressed protein (bre)
  • 6030405P19Rik protein
  • AI429776 protein
  • B830038C02Rik protein
  • BRCC4 protein
  • BRCC45 protein
  • BRE protein
  • im:7141046 protein
  • LOC100231620 protein
  • zgc:110368 protein

Protein level used designations for BRE

BRCA1-A complex subunit BRE , BRCA1/BRCA2-containing complex subunit 45 , Brain and reproductive organ-expressed protein , brain and reproductive organ-expressed (TNFRSF1A modulator) , BRCA1-A complex subunit BRE-like , BRCA1/BRCA2-containing complex, subunit 4 , brain and reproductive organ-expressed protein

GENE ID SPECIES
448242 Xenopus (Silurana) tropicalis
459112 Pan troglodytes
475711 Canis lupus familiaris
702365 Macaca mulatta
100231620 Taeniopygia guttata
100347469 Oryctolagus cuniculus
100396239 Callithrix jacchus
100583596 Nomascus leucogenys
9577 Homo sapiens
362704 Rattus norvegicus
614152 Bos taurus
421417 Gallus gallus
100171610 Pongo abelii
444077 Xenopus laevis
107976 Mus musculus
550474 Danio rerio
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