Branched Chain Amino-Acid Transaminase 1, Cytosolic Proteins (BCAT1)

BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. Additionally we are shipping BCAT1 Antibodies (96) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCAT1 29592 P54690
BCAT1 586 P54687
BCAT1 12035 P24288
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Top BCAT1 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$3,059.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,142.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$382.86
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$384.00
Details

BCAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus) ,
,
Human , , ,
, , ,
Mouse (Murine) ,

More Proteins for Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) Interaction Partners

Human Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) interaction partners

  1. Phenotypic analyses using a lentiviral-mediated BCAT1 short hairpin RNA knockdown revealed that BCAT1 sustains proliferation in addition to migration and invasion and that its overexpression enhanced the capacity of antiestrogen-sensitive cells to grow in the presence of antiestrogens.

  2. The tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression. Importantly, overexpression of BCAT1 decreased the chemosensitivity to cis-diaminedichloroplatinum treatment of PC3 and DU145 cells.

  3. It has been demonstrated that branched-chain amino acid (BCAA) catabolism is activated in human breast cancer, and abolishment of BCAA catabolism by knocking down BCAT1 inhibits breast cancer cell growth by repressing mTOR (show FRAP1 Proteins)-mediated mitochondrial biogenesis and function.

  4. BCAT1 expression is significantly upregulated in human masticatory mucosa during wound healing

  5. Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L (show DOT1L Proteins)-mediated sphere formation and cell migration in breast cancer cells

  6. BCAT1 overexpression is associated with advanced tumour status, and implies adverse clinical outcomes of urothelial carcinoma

  7. BCAT1 is strongly overexpressed in ovarian cancer.

  8. Focal deletions of the BCAT1 were associated with B-cell precursor acute lymphoblastic leukemia.

  9. levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 (show RPS19 Proteins) and RPL11 (show RPL11 Proteins) cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations

  10. Over-expression of BCAT1, a c-Myc (show MYC Proteins) target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma.

Mouse (Murine) Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1) interaction partners

  1. results suggest transcriptional adaptations occur in BCATm (show BCAT2 Proteins) KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes

  2. BCATc as a novel regulator of T cell activation and metabolism

  3. leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 (show BCAT2 Proteins) and BCKDK (show BCKDK Proteins)) that metabolize branched-chain amino acids.

  4. analysis of the biochemical mechanism of BCATm (show BCAT2 Proteins) (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate (show GRIN1 Proteins)

  5. Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6

  6. Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.

  7. These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF (show BDNF Proteins) in a time- and region-dependent fashion.

  8. BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.

  9. BCATm (show BCAT2 Proteins)(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin (show INS Proteins) tolerance & protection from diet-induced obesity

BCAT1 Protein Profile

Protein Summary

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with BCAT1

  • branched chain aminotransferase 1, cytosolic (bcat1)
  • branched chain amino-acid transaminase 1, cytosolic (BCAT1)
  • branched chain amino-acid transaminase 1, cytosolic (bcat1)
  • branched chain amino acid transaminase 1, cytosolic (Bcat1)
  • branched chain aminotransferase 1, cytosolic (Bcat1)
  • BCATc protein
  • BCT1 protein
  • Eca39 protein
  • fj66g02 protein
  • MECA39 protein
  • PNAS121 protein
  • PP18 protein
  • wu:fj66g02 protein
  • zgc:73157 protein

Protein level used designations for BCAT1

branched-chain-amino-acid aminotransferase, cytosolic , branched chain aminotransferase 1, cytosolic , branched chain amino-acid transaminase 1, cytosolic , branched-chain-amino-acid aminotransferase, cytosolic-like , BCAT(c) , placental protein 18 , cytosolic branched-chain amino acid aminotransferase

GENE ID SPECIES
337412 Danio rerio
465345 Pan troglodytes
494683 Xenopus laevis
707321 Macaca mulatta
100068713 Equus caballus
100124778 Xenopus (Silurana) tropicalis
100195810 Salmo salar
100460550 Pongo abelii
100539235 Meleagris gallopavo
100553843 Anolis carolinensis
100591100 Nomascus leucogenys
29592 Rattus norvegicus
586 Homo sapiens
418193 Gallus gallus
486633 Canis lupus familiaris
505926 Bos taurus
443485 Ovis aries
12035 Mus musculus
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