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Breast Cancer Anti-Estrogen Resistance 3 Proteins (BCAR3)

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. Additionally we are shipping BCAR3 Antibodies (44) and BCAR3 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCAR3 29815 Q9QZK2
BCAR3 8412 O75815
Rat BCAR3 BCAR3 310838  
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Top BCAR3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

BCAR3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) Interaction Partners

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. data presented here suggest that Bcar3 could play a role in testis development

  2. many BCAR3-me (show BCAR1 Proteins)diated signaling events in epithelial and mesenchymal cells are independent of p130 (show AKT1 Proteins)Cas association

  3. p130Cas (show BCAR1 Proteins)- and HEF1 (show NEDD9 Proteins)-associated AND-34 may regulate B cell adhesion and motility through a Cdc42 (show CDC42 Proteins)-mediated signaling pathway.

  4. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1 (show NEDD9 Proteins))

Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

  1. BCAR3 is an essential interactor and mediator of HEF1 (show NEDD9 Proteins)-induced migration.

  2. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathway in invasive breast tumors.

  3. BCAR1 (show BCAR1 Proteins) and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance

  4. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin (show INS Proteins) leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 (show SLC2A4 Proteins) translocation.

  5. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

  6. BCAR3 expression may regulate Src (show SRC Proteins) signaling in a BCAR3-p130(cas (show BCAR1 Proteins)) complex-dependent fashion by altering the ability of the Src (show SRC Proteins) SH3 domain to bind the p130(cas (show BCAR1 Proteins)) SBD (show TRAPPC4 Proteins)

  7. BCAR3-p130Cas (show BCAR1 Proteins) complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac (show AKT1 Proteins) activation or discohesion of epithelial breast cancer cells

  8. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes

  9. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner

  10. BCAR3 and NSP1 (show SH2D3A Proteins) are more highly expressed than SH2D3C (SHEP1 (show SH2D3C Proteins)) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

BCAR3 Protein Profile

Protein Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCAR3

  • breast cancer anti-estrogen resistance 3 (BCAR3)
  • breast cancer anti-estrogen resistance 3 (bcar3)
  • breast cancer anti-estrogen resistance 3 (LOC100219682)
  • breast cancer anti-estrogen resistance 3 (Bcar3)
  • AI131758 protein
  • AND-34 protein
  • BCAR3 protein
  • NSP2 protein
  • SH2D3B protein

Protein level used designations for BCAR3

breast cancer anti-estrogen resistance 3 , breast cancer antiestrogen resistance 3 , breast cancer anti-estrogen resistance protein 3 , breast cancer anti-estrogen resistance protein 3-like , p130Cas-binding protein AND-34 , SH2 domain-containing protein 3B , breast cancer antiestrogen resistance 3 protein , dJ1033H22.2 (breast cancer anti-estrogen resistance 3) , novel SH2-containing protein 2

GENE ID SPECIES
424494 Gallus gallus
457032 Pan troglodytes
570610 Danio rerio
100029255 Monodelphis domestica
100059015 Equus caballus
100219682 Taeniopygia guttata
100352424 Oryctolagus cuniculus
100404661 Callithrix jacchus
100447373 Pongo abelii
100475875 Ailuropoda melanoleuca
100036719 Xenopus (Silurana) tropicalis
100593533 Nomascus leucogenys
29815 Mus musculus
8412 Homo sapiens
479941 Canis lupus familiaris
100155981 Sus scrofa
506231 Bos taurus
310838 Rattus norvegicus
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