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C-Type Lectin Domain Family 4, Member D Proteins (CLEC4D)

CLEC4D encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4D Antibodies (49) and CLEC4D Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC4D 338339 Q8WXI8
CLEC4D 17474 Q9Z2H6
CLEC4D 362432 Q69FH1
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Top CLEC4D Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,396.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CLEC4D Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
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Rat (Rattus) ,
,

Top referenced CLEC4D Proteins

  1. Rat (Rattus) CLEC4D Protein expressed in Human Cells - ABIN2009318 : Zelensky, Gready: The C-type lectin-like domain superfamily. in The FEBS journal 2005 (PubMed)
    Show all 2 references for ABIN2009318

  2. Human CLEC4D Protein expressed in Human Cells - ABIN2004304 : Cambi, Figdor: Necrosis: C-type lectins sense cell death. in Current biology : CB 2009 (PubMed)
    Show all 2 references for ABIN2004304

More Proteins for C-Type Lectin Domain Family 4, Member D (CLEC4D) Interaction Partners

Human C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. Results show the molecular mechanism of glycolipid recognition through C-type lectin (show MBL2 Proteins) receptors, which may provide clues to rational design for effective adjuvants.

  2. CLECSF8 functions as an activation receptor on myeloid cells and associates with a novel adaptor molecule

  3. Cross-linking of the receptor leads to a rapid internalization suggesting that CLECSF8 constitutes and endocytic receptor.

Mouse (Murine) C-Type Lectin Domain Family 4, Member D (CLEC4D) interaction partners

  1. Data show that Mincle (show CLEC4E Proteins), the inducible receptor for mycobacterial cord factor, is the key switch for the transition of macrophages from cytokine expression to high nitric oxide production.

  2. MCL regulates the development of vaccine-induced Th17 cells and protective immunity against lethal experimental infection with Blastomyces dermatitidis.

  3. major contributor to activation of innate immunity against M. bovis in experimental model, mirrors Mincle (show CLEC4E Proteins) expression

  4. Clecsf8-/- mice exhibit higher bacterial burdens and increased mortality upon Mycobacterium tuberculosis infection.

  5. These results suggest that MCL positively regulates Mincle (show CLEC4E Proteins) expression through protein-protein interaction via its stalk region, thereby magnifying Mincle (show CLEC4E Proteins)-mediated signaling.

  6. Trehalose 6,6'-dimycolate-induced Mincle (show CLEC4E Proteins) expression is dependent on Dectin-3-mediated NF-kappaB (show NFKB1 Proteins) activation through the CARD9 (show CARD9 Proteins)-BCL10 (show BCL10 Proteins)-MALT1 (show MALT1 Proteins) complex.

  7. Compared to their respective homodimers, Dectin-3 and Dectin-2 (show CLEC6A Proteins) heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections.

  8. Clec4d(-/-) neutrophils did not exhibit any defect in bacterial clearance

  9. These results suggest that Clec4d is an FcRgamma (show FCER1G Proteins)-coupled activating receptor that mediates the adjuvanticity of trehalose-6,6'-dimycolate.

  10. The genomic organization of the MCL gene and the sequence of the promoter region were determined

CLEC4D Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4D

  • C-type lectin domain family 4, member D (CLEC4D)
  • C-type lectin domain family 4, member d (Clec4d)
  • C-type lectin domain family 4, member D (Clec4d)
  • CLEC-6 protein
  • CLEC4D protein
  • CLEC6 protein
  • Clecsf8 protein
  • Mcl protein
  • Mpcl protein

Protein level used designations for CLEC4D

C-type lectin domain family 4, member D , C-type lectin domain family 4 member D , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 , C-type lectin receptor , C-type lectin superfamily member 8 , C-type lectin-like receptor 6 , macrophage C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8 , C-type lectin, superfamily member 8 , macrophage-restricted C-type lectin

GENE ID SPECIES
473405 Pan troglodytes
611536 Canis lupus familiaris
616646 Bos taurus
338339 Homo sapiens
17474 Mus musculus
362432 Rattus norvegicus
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