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CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. Additionally we are shipping CD244 Proteins (23) and CD244 Kits (8) and many more products for this protein.
Showing 10 out of 137 products:
Human Monoclonal CD244 Primary Antibody for FACS - ABIN2661609
Boles, Stepp, Bennett, Kumar, Mathew: 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes. in Immunological reviews 2001
Show all 9 references for ABIN2661609
Human Monoclonal CD244 Primary Antibody for FACS, IF - ABIN2660053
Messmer, Eissmann, Stark, Watzl: CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 9 references for ABIN2660053
Human Monoclonal CD244 Primary Antibody for FACS - ABIN2658548
Lee, Bhawan, Majima, Wei, Nishimura, Yagita, Kumar: Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 8 references for ABIN2658548
Human Polyclonal CD244 Primary Antibody for EIA, WB - ABIN783458
Claus, Meinke, Bhat, Watzl: Regulation of NK cell activity by 2B4, NTB-A and CRACC. in Frontiers in bioscience : a journal and virtual library 2007
Show all 2 references for ABIN783458
Human Monoclonal CD244 Primary Antibody for FACS - ABIN120314
Romero, Zapater, Calvo, Kalko, de la Fuente, Tovar, Ockeloen, Pizcueta, Engel: CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse. in Journal of immunology (Baltimore, Md. : 1950) 2005
Human Polyclonal CD244 Primary Antibody for EIA, IP - ABIN487961
Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. in Journal of immunology (Baltimore, Md. : 1950) 1999
SLAMF4 gene and surface protein expression was down-regulated in CD8 (show CD8A Antibodies)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B (show Gzmb Antibodies) and perforin (show PRF1 Antibodies) than SLAMF4- cells.
GSK-3 (show GSK3b Antibodies) undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (show KLRK1 Antibodies) and 2B4, either individually or in combination.
Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (show CD8A Antibodies)+ T Cell Hyporesponsiveness to Alloantigen
CD8 (show CD8A Antibodies)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (show CD8A Antibodies)(+) T-cell depletion did not further aggravate symptoms of the infection.
CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1 (show GSTT1 Antibodies)-72) or lncRNA-CD244] in the CD244(+)CD8 (show CD8A Antibodies)(+) T-cell subpopulation.
show that in addition to NKG2D (show KLRK1 Antibodies), human CEACAM1 (show CEACAM1 Antibodies) can inhibit NK-cell activation via NKp30 (show NCR3 Antibodies) or 2B4
this study investigates the structural requirements for the recruitment of the human-activating NK-cell receptors NKG2D (show KLRK1 Antibodies) and 2B4 to detergent-resistant membrane fractions in the murine BA/F3 cell line and in the human NK-cell line NKL (show GLIS2 Antibodies).
Study of SAP (show APCS Antibodies) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 functional assay allows identification of all cases
Blockade of 2B4/CD48 (show CD48 Antibodies) interaction resulted in improvement in function via perforin (show PRF1 Antibodies) expression and degranulation as measured by CD107a (show LAMP1 Antibodies) surface mobilization on HTLV-1 specific CD8 (show CD8A Antibodies)+ T cells.
In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Antibodies) is nonfunctional, not only abolishing the activating function of 2B4, but rendering this receptor inhibitory.
2B4 dampens T-independent B cell responses.
DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.
Data show that enforced expression of inhibitor of differentiation protein Id3 (show ID3 Antibodies) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (show CD8A Antibodies)(+) T cells.
Molecular dynamic simulation explains unbinding and unfolding of CD48 (show CD48 Antibodies)-2B4 protein complexes.
Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.
CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.
NKG2D (show KLRK1 Antibodies) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.
blockade of CD28 (show CD28 Antibodies) signals in the presence of preserved CTLA-4 (show CTLA4 Antibodies) signals results in the unique up-regulation of 2B4 on primary CD8 (show CD8A Antibodies)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses
In the absence of SAP (show APCS Antibodies), signaling through the SLAM (show SLAMF1 Antibodies) family members Ly108 (show SLAMF6 Antibodies) and 2B4 resulted in increased recruitment of the SHP-1 (show PTPN6 Antibodies) phosphatase, associated with altered SHP-1 (show PTPN6 Antibodies) localization and decreased activation of Src (show SRC Antibodies) kinases at the synapse.
Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48 (show CD48 Antibodies)-2B4 contact-dependent mechanisms.
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CD244 molecule, natural killer cell receptor 2B4
, natural killer cell receptor 2B4
, NK cell activation inducing ligand NAIL
, NK cell activation-inducing ligand
, NK cell type I receptor protein 2B4
, SLAM family member 4
, signaling lymphocytic activation molecule 4
, CD244 natural killer cell receptor 2B4
, non MHC restricted killing associated
, non-MHC restricted killing associated
, transmembrane NK cell receptor 2B4
, NK cell receptor 2B4