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The protein encoded by CD276 belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Additionally we are shipping CD276 Proteins (31) and CD276 Kits (16) and many more products for this protein.
Showing 10 out of 208 products:
Human Monoclonal CD276 Primary Antibody for FACS - ABIN2663289
Ford, McVicar: TREM and TREM-like receptors in inflammation and disease. in Current opinion in immunology 2009
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Human Polyclonal CD276 Primary Antibody for FACS, IHC - ABIN4900125
Jang, Park, Choi, Kim, Hwang, Baek, Suh, Mun, Suh: 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells. in International journal of oncology 2007
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Human Monoclonal CD276 Primary Antibody for FACS, WB - ABIN4900123
Sucker, Zhao, Real, Heeke, Bielefeld, Maβen, Horn, Moll, Maltaner, Horn, Schilling, Sabbatino, Lennerz, Kloor, Ferrone, Schadendorf, Falk, Griewank, Paschen: Genetic evolution of T-cell resistance in the course of melanoma progression. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
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Human Monoclonal CD276 Primary Antibody for FACS - ABIN317048
Sun, Vale, Leung, Kanwar, Gupta, Krissansen: Mouse B7-H3 induces antitumor immunity. in Gene therapy 2003
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Human Monoclonal CD276 Primary Antibody for FACS - ABIN317045
Chapoval, Ni, Lau, Wilcox, Flies, Liu, Dong, Sica, Zhu, Tamada, Chen: B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. in Nature immunology 2001
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Human Monoclonal CD276 Primary Antibody for FACS, IHC - ABIN969018
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
Show all 2 references for 969018
Human Polyclonal CD276 Primary Antibody for ELISA, IP - ABIN1998403
Loos, Hedderich, Friess, Kleeff: B7-h3 and its role in antitumor immunity. in Clinical & developmental immunology 2010
Human Monoclonal CD276 Primary Antibody for FACS - ABIN4897213
Niehage, Steenblock, Pursche, Bornhäuser, Corbeil, Hoflack: The cell surface proteome of human mesenchymal stromal cells. in PLoS ONE 2011
Anterior pituitary gland progenitor cells containing 4Ig-B7-H3 (CD276) may play a critical role in the immunoendocrine network.
blockage of NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) and/or MAPK p38 (show MAPK1 Antibodies) with their specific inhibitors strongly attenuated B7-H3-amplified inflammatory response with significantly reduced proinflammatory cytokine and chemokine (show CCL1 Antibodies) production, and markedly ameliorated B7-H3-exacerbated disruption of blood-brain barrier and severity of disease status in S. pneumoniae-infected mice.
CD276 is broadly expressed by tumor cells and tumor vasculature but Is dispensable for tumor growth.
this study shows that B7-H3 participates in the development of acute pancreatitis
Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.
Ablation of B7-H3 but Not B7-H4 (show VTCN1 Antibodies) Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
Murine B7-H3 is a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
B7-H3 inhibits T cell proliferation. FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules
The study investigates the role of B7-H3 in pancreatic cancer progression and shows that this protein promotes cancer cell migration and invasiveness in vitro and in vivo.
Graft prolongation achieved by CTLA4 (show CTLA4 Antibodies) Ig was shortened both by B7-H3 blockade and the absence of recipient B7-H3.
Macrophage-tumor cell interaction-induced membrane-bound B7-H3 represents a novel immune escape mechanism which links the pro-inflammatory response to immune tolerance in the tumor milieu.
B7-H3 promotes the oxaliplatin resistance in colorectal cancer cells upregulating the expression of XRCC1 (show XRCC1 Antibodies) via PI3K (show PIK3CA Antibodies)-AKT (show AKT1 Antibodies) pathway.
B7-H3 hijacks SREBP-1 (show SREBF1 Antibodies)/FASN (show FASN Antibodies) signaling mediating abnormal lipid metabolism in lung cancer
BRCC3 may play a role in B7-H3-induced 5-Fu resistance.
We found that B7-H3 promoted the Warburg effect, evidenced by increased glucose uptake and lactate production in B7-H3-expressing cells. B7-H3 also increased the protein levels of HIF1alpha (show HIF1A Antibodies) and its downstream targets, LDHA (show LDHA Antibodies) and PDK1 (show PDK1 Antibodies), key enzymes in the glycolytic pathway
B7-H3 and B7-H4 (show VTCN1 Antibodies) are involved in esophageal squamous cell carcinoma (ESCC) progression and development and their coexpression could be valuable prognostic indicators.
Upregulated sB7-H3 expression in MPEs is correlated with TNM (show ODZ1 Antibodies) stage of NSCLC and may serve as a potential biomarker for NSCLC-derived MPEs
High expression of B7-H3 is associated with Colorectal cancer.
Elevated B7-H3 expression is significantly associated with poor survival in cancer patients. (Meta-analysis)
The results provide novel insights into the function of B7-H3 in cancer, and suggest that targeting of B7-H3 may be a novel alternative to improve current anticancer therapies.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CD276 antigen-like
, CD276 antigen homolog
, CD276 antigen
, B7 homolog 3
, costimulatory molecule