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The protein encoded by CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping CD53 Antibodies (136) and CD53 Kits (3) and many more products for this protein.
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Human CD53 Protein expressed in Wheat germ - ABIN1329990
Zuidscherwoude, Göttfert, Dunlock, Figdor, van den Bogaart, van Spriel: The tetraspanin web revisited by super-resolution microscopy. in Scientific reports 2015
CD53 has a role in macrophage protection against LPS (show TLR4 Proteins)-induced oxidative stress and UVB irradiation
CD53 is associated with population asthma risk via the functional promoter polymorphism -1560 C>T.
SNP rs6679497 in gene CD53 showed significant association with TNFalpha (show TNF Proteins) levels (P=0.001); no association of this SNP was observed with osteoarthritis
Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass.
Analysis of lymphocyte subsets showed that the total number of CD3 (show CD3 Proteins)+, CD4 (show CD4 Proteins)+, CD8 (show CD8A Proteins)+ and CD56 (show NCAM1 Proteins)+ lymphocytes increased after the intensive protocol before falling below pre-exercise values at 1 h post-exercise.
The paradox is that lymphocytes from RA patients are believed to resist apoptosis, and we suggest that the elevated expression of CD53, which results from the increased oxidative stress, may protect against apoptosis.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.
cell surface glycoprotein CD53
, leukocyte surface antigen CD53
, CD53 antigen
, CD53 glycoprotein
, CD53 tetraspan antigen
, antigen MOX44 identified by monoclonal antibody MRC-OX44
, cell surface antigen
, transmembrane glycoprotein
, leukocyte antigen MRC OX-44