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The protein encoded by CLK4 belongs to the CDC2-like protein kinase (CLK) family. Additionally we are shipping CLK4 Antibodies (39) and CLK4 Kits (2) and many more products for this protein.
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Clk1/4 expression induced by stress-responsive splicing serves to maintain the phosphorylation state of SR proteins.
Clk1 (show CDK11B Proteins), Clk2 (show CLK2 Proteins) and Clk4 prevent chromatin breakage by regulating the Aurora B (show AURKB Proteins)-dependent abscission checkpoint.
Cdc2 (show CDK1 Proteins)-like kinases and DNA topoisomerase I (show TOP1 Proteins) regulate alternative splicing of tissue factor (show F3 Proteins) in human endothelial cells.
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.
CDC-like kinase 4
, dual specificity protein kinase CLK4
, protein serine threonine kinase Clk4