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The protein encoded by CDKAL1 is a member of the methylthiotransferase family. Additionally we are shipping CDKAL1 Proteins (4) and CDKAL1 Kits (2) and many more products for this protein.
Showing 10 out of 40 products:
Human Polyclonal CDKAL1 Primary Antibody for ELISA, WB - ABIN570672
Brambillasca, Altkrueger, Colombo, Friederich, Eickelmann, Mark, Borgese, Solimena: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. in The Journal of biological chemistry 2012
Dog (Canine) Polyclonal CDKAL1 Primary Antibody for ELISA - ABIN451799
Zeggini, Weedon, Lindgren, Frayling, Elliott, Lango, Timpson, Perry, Rayner, Freathy, Barrett, Shields, Morris, Ellard, Groves, Harries, Marchini, Owen, Knight, Cardon, Walker, Hitman, Morris, Doney et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. ... in Science (New York, N.Y.) 2007
our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (show TNF Antibodies) therapies among Psoriasis patients
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Antibodies), ADRA2A (show ADRA2A Antibodies), CDKAL1, CDKN2A (show CDKN2A Antibodies)/B, GRB10 (show GRB10 Antibodies), and TCF7L2 (show TCF7L2 Antibodies)
rs10946398 associated with markers of impaired insulin (show INS Antibodies) secretion
We observed novel selection signals in CDKAL1 and NEGR1 (show NEGR1 Antibodies), well-known diabetes and obesity susceptibility genes
study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1 (show JAZF1 Antibodies), and rs35767 in IGF1 (show IGF1 Antibodies) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
The rs7754840 and rs7756992 SNPs of the CDKAL1 gene were found to be associated with Gestational Diabetes Mellitus in this south Indian population.
study identified the association between type 2 diabetes risk variants in CDKAL1 and birthweight in Chinese Han individuals, and the carrier of risk allele within SRR (show SRR Antibodies) had the trend of reduced birthweight.
Provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes.
The results support a central role of CDKAL1 and TCF7L2 (show TCF7L2 Antibodies) in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.
CDKAL1 gene rs7756992 A/G polymorphism was significantly associated with T2DM. The person with G allele of CDKAL1 gene rs7756992 A/G polymorphism might be predisposed to T2DM.
CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet
Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.
Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (show LYZ Antibodies))(UUU) and that it is required for the accurate translation of AAA (show AAAS Antibodies) and AAG (show C16orf35 Antibodies) codons.
CDKAL1 controls first-phase insulin (show INS Antibodies) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (show CA2 Antibodies)+) channels through pathways other than CDK5 (show CDK5 Antibodies)-mediated regulation
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.
CDK5 regulatory subunit-associated protein 1-like 1
, tRNA-t(6)A37 methylthiotransferase
, threonylcarbamoyladenosine tRNA methylthiotransferase
, CDK5 regulatory subunit associated protein 1-like 1