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The protein encoded by CDKAL1 is a member of the methylthiotransferase family. Additionally we are shipping CDKAL1 Antibodies (39) and CDKAL1 Kits (2) and many more products for this protein.
Showing 4 out of 4 products:
our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (show TNF Proteins) therapies among Psoriasis patients
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Proteins), ADRA2A (show ADRA2A Proteins), CDKAL1, CDKN2A/B, GRB10 (show GRB10 Proteins), and TCF7L2 (show TCF7L2 Proteins)
rs10946398 associated with markers of impaired insulin (show INS Proteins) secretion
We observed novel selection signals in CDKAL1 and NEGR1 (show NEGR1 Proteins), well-known diabetes and obesity susceptibility genes
study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1 (show JAZF1 Proteins), and rs35767 in IGF1 (show IGF1 Proteins) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
The rs7754840 and rs7756992 SNPs of the CDKAL1 gene were found to be associated with Gestational Diabetes Mellitus in this south Indian population.
study identified the association between type 2 diabetes risk variants in CDKAL1 and birthweight in Chinese Han individuals, and the carrier of risk allele within SRR (show SRR Proteins) had the trend of reduced birthweight.
Provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes.
The results support a central role of CDKAL1 and TCF7L2 (show TCF7L2 Proteins) in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.
CDKAL1 gene rs7756992 A/G polymorphism was significantly associated with T2DM. The person with G allele of CDKAL1 gene rs7756992 A/G polymorphism might be predisposed to T2DM.
CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet
Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.
Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (show LYZ Proteins))(UUU) and that it is required for the accurate translation of AAA (show AAAS Proteins) and AAG (show C16orf35 Proteins) codons.
CDKAL1 controls first-phase insulin (show INS Proteins) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (show CA2 Proteins)+) channels through pathways other than CDK5 (show CDK5 Proteins)-mediated regulation
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.
CDK5 regulatory subunit-associated protein 1-like 1
, tRNA-t(6)A37 methylthiotransferase
, threonylcarbamoyladenosine tRNA methylthiotransferase
, CDK5 regulatory subunit associated protein 1-like 1