C-Type Lectin Domain Family 1, Member B Proteins (CLEC1B)

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. Additionally we are shipping C-Type Lectin Domain Family 1, Member B Antibodies (124) and C-Type Lectin Domain Family 1, Member B Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CLEC1B CLEC1B 500336  
CLEC1B 51266 Q9P126
CLEC1B 56760 Q9JL99
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Top C-Type Lectin Domain Family 1, Member B Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_HEK-293 Mouse Fc Tag 100 μg Log in to see 10 to 12 Days
$587.01
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 20 to 21 Days
$382.80
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$418.88
Details

CLEC1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) , ,
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More Proteins for C-Type Lectin Domain Family 1, Member B (CLEC1B) Interaction Partners

Human C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. Data (including data from studies using cells from knockout mice) suggest that CLEC2/CLEC2R signaling is dependent on thromboxane A2 generation and is potentiated by co-stimulation with different GNAQ (show GNAQ Proteins) agonists. (CLEC2 = C-type lectin (show MBL2 Proteins) CLEC2; CLEC2R = CLEC2 receptor; GNAQ (show GNAQ Proteins) = guanine nucleotide-binding protein (show COASY Proteins) G[q] subunit alpha)

  2. NZ-1 inhibits the hPDPN-CLEC-2 interaction and is also useful for anti-PA tag MAb.The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy

  3. CLEC2 prevents expression of PI3K (show PIK3CA Proteins) subunits, in a SYK (show SYK Proteins)-dependent manner, to suppress the invasive activities of gastric cancer cells.

  4. CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.

  5. Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation (show CD36 Proteins) of C (show GP6 Proteins)D36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2).

  6. PI3K (show PIK3CA Proteins) and Tec (show NR4A3 Proteins) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Proteins) phosphorylation downstream of the CLEC-2 receptor

  7. fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway

  8. Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade

  9. A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation.

  10. The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2.

Mouse (Murine) C-Type Lectin Domain Family 1, Member B (CLEC1B) interaction partners

  1. a novel mechanism of Deep vein thrombosis, whereby CLEC-2 and upregulation of podoplanin (show PDPN Proteins) expression in the venous wall trigger thrombus formation

  2. A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN (show PDPN Proteins) on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.

  3. A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis

  4. Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks (show MKKS Proteins)).

  5. Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36 (show CD36 Proteins)/GPVI (show GP6 Proteins) (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2).

  6. Podoplanin (show PDPN Proteins) and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.

  7. PI3K and Tec (show NR4A3 Proteins) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Proteins) phosphorylation downstream of the CLEC-2 receptor

  8. CLEC-2 signaling promotes adhesion to Podoplanin (show PDPN Proteins) and regulation of Podoplanin (show PDPN Proteins) signaling, thereby contributing to lymphatic vasculature development.

  9. Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN (show PDPN Proteins) receptor CLEC-2, PDPN (show PDPN Proteins) endowed FRCs with contractile function and exerted tension within the reticulum.

  10. Functional studies of platelets from Ceacam2 (show CEACAM2 Proteins)(-/-)-deficient mice (Cc2 (show TSG101 Proteins)(-/-)) revealed that CEACAM2 (show CEACAM2 Proteins) serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI (show GP6 Proteins))-FcRgamma (show FCER1G Proteins)-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling

C-Type Lectin Domain Family 1, Member B (CLEC1B) Protein Profile

Protein Summary

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000

Gene names and symbols associated with CLEC1B

  • C-type lectin domain family 1, member B (CLEC1B)
  • C-type lectin domain family 1, member B (Clec1b)
  • C-type lectin domain family 1, member B (LOC100346882)
  • C-type lectin domain family 1, member b (Clec1b)
  • 1810061I13Rik protein
  • Clec-2 protein
  • CLEC1B protein
  • Clec2 protein
  • CLEC2B protein
  • PRO1384 protein
  • QDED721 protein
  • RGD1563517 protein

Protein level used designations for CLEC1B

C-type lectin domain family 1, member B , C-type lectin domain family 1 member B , c-type lectin domain family 1 member B-like , C-type lectin-like receptor 2 , C-type lectin-like receptor-2 , CLEC-2

GENE ID SPECIES
465283 Pan troglodytes
486696 Canis lupus familiaris
500336 Rattus norvegicus
717404 Macaca mulatta
784092 Bos taurus
100346882 Oryctolagus cuniculus
51266 Homo sapiens
56760 Mus musculus
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