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CDH16 is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Additionally we are shipping CDH16 Antibodies (24) and and many more products for this protein.
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CDH17 is a sensitive marker for midgut WDNETs, and the CDH17+/CDX2 (show CDX2 Proteins)-/TTF1 (show NKX2-1 Proteins)- phenotype was found to be sensitive (92%) and specific (91%) for hindgut well-differentiated neuroendocrine tumours (WDNETs).
Using a lentiviral system as a delivery mediator of RNA interference, we found that inhibition of CDH17 can lead to reduce proliferation and increase apoptosis of gastric cancer cell line MKN28 in vitro and significantly diminish their tumorigenicity in vivo. Our results of the present study suggest that CDH17 may be a promising candidate for the therapeutic targeting of gastric cancer.
In stomach adenocarcinomas, CDH17 positively stained 64.0% (112 of 175) of tissues, compared to CK20 (show KRT20 Proteins) and CDX2 (show CDX2 Proteins), where staining was observed in only 24.6% (43 of 175) and 46.9% (82 of 175), respectively.
These data indicate that knockdown of LIcadherin facilitates the invasion of cancer cells by degrading extracellular matrix components via activation of MMP2 (show MMP2 Proteins) and 9, and increases cancer cell adhesion and migration via altered expression of galectin3.
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Mutations in CDH17 gene is associated with idiopathic hypereosinophilic syndrome.
Review/Meta-analysis: data reflect the role of CDH17 in tumor proliferation and metastasis among gastric cancer patients.
CDH17 is a sensitive (81%) and highly specific (100%) marker for metanephric adenoma.
RGD motif present in cadherin 17 induces integrin activation and tumor growth
Data suggest that combined tumor expression of CDH17 (cadherin-17) and SATB2 (special AT-rich sequence binding protein 2 (show SATB2 Proteins)) may be used as diagnostic biomarkers in subjects with medullary carcinoma of the large intestine (colon; cecum).
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.
, kidney-specific cadherin
, HPT-1 cadherin
, LI cadherin
, human intestinal peptide-associated transporter HPT-1
, human peptide transporter 1
, intestinal peptide-associated transporter HPT-1
, liver-intestine cadherin