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Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit Proteins (CACNA1B)

The protein encoded by CACNA1B is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. Additionally we are shipping CACNA1B Antibodies (48) and CACNA1B Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CACNA1B 774 Q00975
CACNA1B 12287 O55017
Rat CACNA1B CACNA1B 257648  
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Top CACNA1B Proteins at antibodies-online.com

Showing 2 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

CACNA1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) Interaction Partners

Human Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) interaction partners

  1. These results do not support a causal association between the CACNA1B c.4166G>A; (p.R1389H) variant and M-D.

  2. the consensus motifs of S-nitrosylation were much more abundant in Cav2.2 than in Cav1.2 (show CACNA1C Proteins) and Cav2.1 (show CACNA1A Proteins).

  3. AP-1 (show FOSB Proteins) binding motifs, present only in exon 37a, enhance intracellular trafficking of exon 37a-containing Ca(V)2.2 to the axons and plasma membrane of rat dorsal root ganglia neurons

  4. CACNA1B mutation is linked to unique myoclonus-dystonia syndrome.

  5. The first disease connection for Cav2.2 channels [review]

  6. The interaction between LC1 and the N-type channel (CaV2.2 channel) was demonstrated.

  7. with membrane-localized CaV beta subunits, CaV2.2 channels are subject to Gbetagamma-mediated voltage-dependent inhibition, whereas cytosol-localized beta subunits confer more effective PIP2-mediated voltage-independent regulation

  8. new mechanistic perspectives, and reveal unexpected variations in determinants, underlying inhibition of Ca(V)1.2 (show CACNA1C Proteins)/Ca(V)2.2 channels by distinct RGK GTPases.

  9. Ca(2 (show CA2 Proteins)+) exits the channel through the Cav2.2.

  10. polymorphisms and haplotypes in the human CACNA1B gene show significant differences between cerebral infarction and control patients

Mouse (Murine) Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) interaction partners

  1. Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Proteins) channels by Gi/o or Gq protein pathways depending on its mode of activation.

  2. Blockade of Cav2.2 in inflammatory arthritis leads to up-regulation of the osteoclast activator RANKL (show TNFSF11 Proteins) and concomitant joint and bone destruction.

  3. Results identified altered synaptic transmission in the olfactory system of Cav2.2-deficient mice and suggest that the olfactory system could become an attractive model to learn more about this channel and the consequences of its removal

  4. Gaba B receptors were found to mediate Cav2.2 channel inhibition.

  5. Cav2.1 (show CACNA1A Proteins)-2.3 have unique contributions to the dynamics at the Schaffer collateral synapse that are engaged by the complex patterns of afferent activity seen in vivo

  6. Results demonstrate that sensory neurons from Nf1 (show NF1 Proteins)+/- mice, exhibit increased N-type (Cav2.2) ICa and likely account for the increased release of substance P (show TAC1 Proteins) and calcitonin gene-related peptide (show CALCA Proteins) that occurs in Nf1 (show NF1 Proteins)+/- sensory neurons

  7. data suggest that the different roles that Ca(V)2.1 (show CACNA1A Proteins) and Ca(V)2.2 play in MNC secretion may be a result of the different levels of expression of Ca(V)2.1 (show CACNA1A Proteins) in VP and OT MNCs

  8. CaV2.2 and alpha2delta-1 are intimately associated at the plasma membrane

  9. These findings identify an interaction between ankyrin-B and both Cav2.1 (show CACNA1A Proteins) and Cav2.2 at the amino acid level that is necessary for proper Cav2.1 (show CACNA1A Proteins) and Cav2.2 targeting in vivo.

  10. Blocking Cav2.2 channels abolishes respiratory activity in all brainstem slices from Cav2.1 (show CACNA1A Proteins) genetically ablated animals.

Rabbit Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B) interaction partners

  1. The monomeric G proteins AGS1 (show RASD1 Proteins) and Rhes (show RASD2 Proteins) selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.

CACNA1B Protein Profile

Protein Summary

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CACNA1B

  • calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B)
  • calcium channel, voltage-dependent, N type, alpha 1B subunit (Cacna1b)
  • alpha(1B) protein
  • AW050276 protein
  • AW060892 protein
  • AW822256 protein
  • BIII protein
  • CACNL1A5 protein
  • CACNN protein
  • Cav2.2 protein
  • Cchn1a protein

Protein level used designations for CACNA1B

calcium channel, voltage-dependent, L type, alpha 1B subunit , voltage-dependent N-type calcium channel subunit alpha-1B , calcium channel, voltage-dependent, N type, alpha 1B subunit , Cav2.2 voltage-gated Ca2+ channel , brain calcium channel III , calcium channel alpha12.2 subunit , calcium channel, L type, alpha-1 polypeptide , calcium channel, N type , calcium channel, voltage-dependent, alpha 1B subunit, N type , voltage-gated calcium channel alpha subunit Cav2.2 , voltage-gated calcium channel subunit alpha Cav2.2 , BIII , voltage gated N-type calcium channel Ca(v)2.2 , CHCACHA1B , N-type voltage-gated calcium channel alpha1B subunit ChCaChA1B , calcium channel BIII

GENE ID SPECIES
282410 Bos taurus
464893 Pan troglodytes
480660 Canis lupus familiaris
721452 Macaca mulatta
774 Homo sapiens
12287 Mus musculus
257648 Rattus norvegicus
374169 Gallus gallus
100008979 Oryctolagus cuniculus
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