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Carboxylesterase 1 Proteins (CES1)

CES1 encodes a member of the carboxylesterase large family. Additionally we are shipping Carboxylesterase 1 Antibodies (60) and Carboxylesterase 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CES1 CES1 24346 P10959
CES1 1066 P23141
CES1 12623 Q8VCC2
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Top Carboxylesterase 1 Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days

CES1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for Carboxylesterase 1 (CES1) Interaction Partners

Human Carboxylesterase 1 (CES1) interaction partners

  1. The structure and activity of glycosylated and aglycosylated human CES1 has been determined.

  2. CES1 c.428G>A single nucleotide variation increases clopidogrel active metabolite concentrations and antiplatelet effects by reducing clopidogrel hydrolysis to inactive metabolites

  3. CEH (show EPHX2 Proteins) is an important regulator in enhancing cholesterol elimination.

  4. study found an association between two CES1 SNP markers and the occurrence of sadness as a side effect of short-acting methylphenidate

  5. After oral administration of dabigatran etexilate to humans, DABE is hydrolyzed by intestinal CES2 to the intermediate M2 metabolite followed by hydrolysis of M2 to DAB in the liver by CES1.

  6. The conversion of 2-oxo-ticlopidine to M1 was further confirmed with recombinant paraoxonase 1 (PON1 (show PON1 Proteins)) and CES1.

  7. CES1 plays a role in the metabolism of several drugs.

  8. An influence of carboxylesterase 1 -75 T>G polymorphism on the worsening of appetite reduction with MPH (show PVRL2 Proteins) treatment in youths with ADHD.

  9. PMPMEase overexpression in colorectal cancer and cancer cell death stemming from its inhibition is an indication of its possible role in cancer progression and a target for chemopreventive agents

  10. carboxylesterase I controls RhoA (show RHOA Proteins) methylation

Pig (Porcine) Carboxylesterase 1 (CES1) interaction partners

  1. One novel isoform termed alternative pig liver esterase (show ESD Proteins) (APLE) was found to hydrolyze methyl-(2R,4E)-5-chloro-2-isopropyl-4-pentenoate in a highly stereoselective manner (E>200).

  2. The objective of this study is to explore the mechanisms that regulate TGH expression in porcine adipocyte and its role in fasting-induced (show C10orf10 Proteins) and Isoproterenol-stimulated lipolysis in porcine primary adipocytes.

  3. PMPMEase was purified to apparent homogeneity from porcine liver supernatant.

Mouse (Murine) Carboxylesterase 1 (CES1) interaction partners

  1. Hepatic Ces1g/Es-x plays a critical role in limiting hepatic steatosis, very low-density lipoprotein assembly and in augmenting insulin (show INS Proteins) sensitivity.

  2. Data indicate that organic anion-transporting polypeptides Oatp1a/1b-null mice had increased levels of carboxylesterase (Ces) enzymes, which caused higher conversion of irinotecan to SN-38 in plasma, potentially complicating pharmacokinetic analyses.

  3. Hepatic CES1 plays a critical role in regulating both lipid and carbohydrate metabolism and FXR (show NR1H4 Proteins)-controlled lipid homeostasis

Carboxylesterase 1 (CES1) Protein Profile

Protein Summary

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Gene names and symbols associated with Carboxylesterase 1 Proteins (CES1)

  • carboxylesterase 1C (Ces1c)
  • carboxylesterase 1 (CES1)
  • liver carboxylesterase 1 (CpipJ_CPIJ013026)
  • liver carboxylesterase 1 (CpipJ_CPIJ016339)
  • liver carboxylesterase (LOC100009551)
  • carboxylesterase 1-like (LOC508916)
  • carboxylesterase 1A (Ces1a)
  • carboxylesterase 1E (Ces1e)
  • carboxylesterase 1G (Ces1g)
  • ACAT protein
  • APLE protein
  • CE-1 protein
  • CEH protein
  • Ces-1 protein
  • CES-K1 protein
  • Ces1 protein
  • CES2 protein
  • CESDD1 protein
  • Es1 protein
  • Es2 protein
  • Es22 protein
  • hCE-1 protein
  • HMSE protein
  • HMSE1 protein
  • PCE-1 protein
  • PMPMEase protein
  • REH protein
  • Ses-1 protein
  • SES1 protein
  • TGH protein

Protein level used designations for Carboxylesterase 1 Proteins (CES1)

esterase 1 , E1 , REH , NREH , ES-THET , esterase-2 , carboxyesterase ES-1 , retinyl ester hydrolase , liver carboxylesterase 1 , neutral retinyl ester hydrolase , Esterase 2 member of carboxylesterase-cluster 1 , esterase 2, member of carboxylesterase-cluster 1 , carboxylesterase 1 , carboxylesterase 1 (monocyte/macrophage serine esterase 1) , acyl coenzyme A:cholesterol acyltransferase , acyl-coenzyme A:cholesterol acyltransferase , brain carboxylesterase hBr1 , carboxylesterase 2 (liver) , cholesteryl ester hydrolase , cocaine carboxylesterase , egasyn , human monocyte/macrophage serine esterase 1 , methylumbelliferyl-acetate deacetylase 1 , monocyte/macrophage serine esterase , serine esterase 1 , triacylglycerol hydrolase , carboxylesterase D1 , alternative pig liver esterase , liver carboxylesterase , prenylated methylated protein methyl esterase , proline-beta-naphthylamidase , carboxylesterase 1-like , ES-HTEL , carboxyesterase ES-3 , esterase 22 , liver carboxylesterase 3 , pI 5.5 esterase , ES-x

24346 Rattus norvegicus
454097 Pan troglodytes
493774 Felis catus
699486 Macaca mulatta
6045866 Culex quinquefasciatus
6050034 Culex quinquefasciatus
100009551 Oryctolagus cuniculus
100144615 Monodelphis domestica
1066 Homo sapiens
403643 Canis lupus familiaris
397478 Sus scrofa
508916 Bos taurus
679817 Rattus norvegicus
29225 Rattus norvegicus
12623 Mus musculus
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