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Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Proteins (CILP)

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. Additionally we are shipping Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Antibodies (43) and Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CILP CILP 315761  
CILP 8483 O75339
CILP 214425 Q66K08
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Top Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details

CILP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)
,

More Proteins for Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) Interaction Partners

Human Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) interaction partners

  1. CILP is involved in the etiology of intervertebral disc degeneration among young adults.

  2. The researchers found that the single nucleotide polymorphism (1184T/C) of the CILP gene is associated an increased risk of lumbar disc degeneration in male athletes.

  3. CILP regulates TGF-beta (show TGFB1 Proteins) signaling and that this regulation has a crucial role in the etiology and pathogenesis of LDD.

  4. These observations, together with the finding that CILP protein binds and inhibits TGF-beta1 (show TGFB1 Proteins), suggest that CILP and TGF-beta1 (show TGFB1 Proteins) may form a functional feedback loop that controls chondrocyte metabolism.

  5. SNP analysis suggested that the CILP gene is not a major risk factor for symptoms of lumbar disc disease in Finnish or Chinese populations.

  6. the CILP gene 1184T/C polymorphism is a significant risk factor for lumbar disc degeneration occurrence in Japanese collegiate judo athletes

Mouse (Murine) Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) interaction partners

  1. Overexpression of CILP in the nucleus pulposus cells promotes disc degeneration, indicating that CILP plays a direct role in the pathogenesis of lumbar disc disease.

Cartilage Intermediate Layer Protein, Nucleotide Pyrophosphohydrolase (CILP) Protein Profile

Protein Summary

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins\; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.

Gene names and symbols associated with CILP

  • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (CILP)
  • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (cilp)
  • ClpX caseinolytic peptidase X homolog (E. coli) (CLPX)
  • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (LOC100224477)
  • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase (Cilp)
  • 9830114D16 protein
  • C130036G17Rik protein
  • CILP protein
  • CILP-1 protein
  • HsT18872 protein
  • im:7137994 protein
  • NTPPH protein

Protein level used designations for CILP

cartilage intermediate layer protein, nucleotide pyrophosphohydrolase , ClpX caseinolytic protease X homolog , cartilage intermediate layer protein 1-like , cartilage intermediate layer protein 1 , cartilage intermediate layer protein 1 C1 , cartilage intermediate layer protein 1 C2 , cartilage intermediate-layer protein , CILP-1 , nucleotide pyrophosphohydrolase

GENE ID SPECIES
415533 Gallus gallus
453514 Pan troglodytes
497360 Danio rerio
505573 Bos taurus
100138870 Bos taurus
100224477 Taeniopygia guttata
100390902 Callithrix jacchus
100475451 Ailuropoda melanoleuca
100541878 Meleagris gallopavo
100586830 Nomascus leucogenys
315761 Rattus norvegicus
8483 Homo sapiens
487603 Canis lupus familiaris
214425 Mus musculus
397672 Sus scrofa
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