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Cell Cycle and Apoptosis Regulator 2 Proteins (CCAR2)

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Additionally we are shipping CCAR2 Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCAR2 57805 Q8N163
CCAR2    
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Top CCAR2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CCAR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaction Partners

Human Cell Cycle and Apoptosis Regulator 2 (CCAR2) interaction partners

  1. Proteosome-mediated degradation and poly-ubiquitination of AR were increased with the knock-down of DBC1 (show DBC1 Proteins).

  2. The results suggest that the PP4 (show ANXA5 Proteins)-mediated dephosphorylation of DBC1 (show DBC1 Proteins) is necessary for efficient damage responses in cells.

  3. These results indicate that the expression of DBC1 and BRCA1 are closely related with in the progression of ovarian carcinomas

  4. the results indicated that DBC1 (show DBC1 Proteins) promotes anoikis resistance in gastric cancer cells by regulating NF-kappaB (show NFKB1 Proteins) activity and may thus be a new therapeutic target for preventing potential metastasis

  5. DBC1 (show DBC1 Proteins) modification by Small Ubiquitin-like Modifier 2 (show SUMO2 Proteins)/3 is crucial for p53 (show TP53 Proteins) transactivation under genotoxic stress.

  6. molecular mechanism underlying DBC1 (show DBC1 Proteins) function in PEA3 (show ETV4 Proteins)-mediated transcription involves inhibition of SIRT1 (show SIRT1 Proteins) interaction with PEA3 (show ETV4 Proteins) and of SIRT1 (show SIRT1 Proteins)-mediated deacetylation of PEA3 (show ETV4 Proteins)

  7. DBC1 (show DBC1 Proteins) might promote adipose tissue inflammation and senescence in obese subjects

  8. this study provides insight into the structure and evolution of DBC1 and CCAR1, which may impact future studies on the biological functions of these proteins.

  9. Although DBC1 (show DBC1 Proteins) gene expression was reduced in adipose tissue from obese subjects, it was negatively associated with ADIPOQ (show ADIPOQ Proteins) gene expression in VAT, suggesting that DBC1 (show DBC1 Proteins) might promote visceral adipose tissue dysfunction.

  10. These results clearly indicate a novel mechanism in which CCAR2 may regulate the transcriptional activation function of LXRalpha (show NR1H3 Proteins) due to its specific inhibition of SIRT1 (show SIRT1 Proteins) and serve to regulate cellular proliferation.

CCAR2 Protein Profile

Protein Summary

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.

Gene names and symbols associated with CCAR2

  • cell cycle and apoptosis regulator 2 (CCAR2)
  • DBC-1 protein
  • DBC1 protein
  • KIAA1967 protein
  • NET35 protein
  • p30 DBC protein
  • p30DBC protein

Protein level used designations for CCAR2

DBIRD complex subunit KIAA1967 , deleted in breast cancer 1 , p30 DBC protein

GENE ID SPECIES
57805 Homo sapiens
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