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The protein encoded by CETN3 contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Additionally we are shipping Centrin, EF-Hand Protein, 3 Antibodies (31) and many more products for this protein.
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Human CETN3 Protein expressed in Escherichia coli (E. coli) - ABIN667815
Middendorp, Paoletti, Schiebel, Bornens: Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. in Proceedings of the National Academy of Sciences of the United States of America 1997
Cetn3 inhibits Mps1 (show IDUA Proteins) autophosphorylation at Thr (show TRH Proteins)-676, a known site of T-loop autoactivation, and interferes with Mps1 (show IDUA Proteins)-dependent phosphorylation of Cetn2 (show CETN2 Proteins). The cellular overexpression of Cetn3 attenuates the incorporation of Cetn2 (show CETN2 Proteins) into centrioles and centrosome reduplication, whereas depletion of Cetn3 generates extra centrioles.
could be classified as a Ca(2 (show CA2 Proteins)+) sensor protein
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.
centrin, EF-hand protein, 3 (CDC31 homolog)
, centrin 3
, centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
, CDC31 yeast homolog
, EF-hand superfamily member