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CNTROB encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Additionally we are shipping and many more products for this protein.
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Human Polyclonal CNTROB Primary Antibody for EIA, WB - ABIN951474
Lee, Jeong, Jeong, Rhee: Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosis. in The Journal of biological chemistry 2010
Show all 3 references for 951474
Human Polyclonal CNTROB Primary Antibody for WB - ABIN530406
Hori, Peddie, Collinson, Toda: Centriolar satellite- and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly. in Molecular biology of the cell 2015
cytoplasmic centrobin has roles in noncentrosomal microtubule formation in specific cell types and during the cell cycle
Centrobin plays a role in the stability and centriole elongation function of CPAP (show CENPJ Antibodies) and limits the centriole length.
Centrobin-CPAP (show CENPJ Antibodies) interaction is critical for the recruitment of CPAP (show CENPJ Antibodies) to procentrioles to promote the elongation of daughter centrioles and for the persistence of CPAP (show CENPJ Antibodies) on preexisting mother centrioles.
it is proposed that Centrobin might regulate microtubule nucleation and organization by controlling the amount of pericentriolar matrix
NEK2 (show NEK2 Antibodies) phosphorylation antagonizes the microtubule stabilizing activity of centrobin.
Our results indicate that genetic polymorphisms of centrobin and Nek2 are related to breast cancer susceptibility in Chinese Han women.
Centrobin facilitates the elongation and stability of centrioles via its interaction with tubulins.
Data propose that centrobin functions as a microtubule stabilizing factor and PLK1 (show PLK1 Antibodies) enhances centrobin activity for proper spindle formation during mitosis.
a requirement of Centrobin in maintaining centrosome integrity, which in turn promotes anchoring of mitotic spindle to the centrosomes.
Inhibition of p38 (show CRK Antibodies) activity or downregulation of p38 (show CRK Antibodies) expression could overcome the cell-cycle arrest caused by centrobin depletion.
Centrobin may be a possible substrate of Nek2 (show NEK2 Antibodies) responsible for the meiotic spindle assembly in the mouse oocytes.
Data show that a residual amount of centrobin was detected at the centrosomes of the resting cells, suggesting its role for maintaining integrity of the centrosome, especially of the daughter centriole in the cells.
The phenotypic similarities of the Nip2/centrobin- and Nek2 (show NEK2 Antibodies)-suppressed embryos suggest that Nip2/centrobin may be a substrate of Nek2 (show NEK2 Antibodies) that is required for mitotic spindle assembly in early mouse embryos.
This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
centrobin, centrosomal BRCA2 interacting protein
, LYST-interacting protein LIP8
, LYST-interacting protein 8
, centrosomal BRCA2-interacting protein