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The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. Additionally we are shipping CENPT Antibodies (26) and CENPT Kits (15) and many more products for this protein.
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These results support the existence of 2 pathways for kinetochore assembly directed by CENP-C and CENP-T/W, which can be reconstituted in Xenopus egg extracts.
FACT chaperone stabilizes the soluble CENP-T/-W complex in the cell and promotes dynamics of exchange, enabling CENP-T/-W deposition at centromeres.
We used a synthetic system to dissect how CenH3(CENP-A (show CENPA Proteins)) contributes to the accumulation of CENP-C and CENP-T, two key components that are necessary for the formation of functional kinetochores
CENP-T directly interacts with Ndc80 (show NDC80 Proteins), which in turn promotes KNL1/Mis12 (show MIS12 Proteins) complex recruitment at kinetochores during chromosome segregation.
CSN5 regulates the stability of the inner kinetochore components CENP-T and CENP-W, providing the first direct link between CSN5 and the mitotic apparatus, highlighting the role of CSN5 as a multifunctional cell cycle regulator.
CENP-T provides a structural platform for outer kinetochore assembly.
results reveal the molecular function of CENP-T proteins and demonstrate how the Ndc80 (show NDC80 Proteins) complex is anchored to centromeres in a manner that couples chromosome movement to spindle dynamics
The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations.
Study demonstrates that CENP-W (show CENPW Proteins) forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3 (show HIST3H3 Proteins), but not with CENP-A (show CENPA Proteins), in centromeric regions.
CENP-T exchange into centromeres is restricted to the S-phase of the cell cycle as revealed by FRAP (show FRAP1 Proteins), suggesting a coreplicational loading mechanism.
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006
centromere protein T
, centromere protein T-like
, interphase centromere complex protein 22