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Ceramide Synthase 6 Proteins (CERS6)

May be involved in sphingolipid synthesis or its regulation (By similarity).. Additionally we are shipping Ceramide Synthase 6 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CERS6 253782 Q6ZMG9
CERS6 241447 Q8C172
Rat CERS6 CERS6 366065  
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Top Ceramide Synthase 6 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CERS6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Ceramide Synthase 6 (CERS6) Interaction Partners

Human Ceramide Synthase 6 (CERS6) interaction partners

  1. Identification of CerS6 and ceramide pathways as a novel Methotrexate target.

  2. stichoposide D inhibits growth of experimental leukemia by activating Fas (show FAS Proteins)/ceramide synthase 6/p38 (show CRK Proteins) kinase in lipid rafts

  3. CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.

  4. Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.

  5. On the basis of its pivotal role in regulating cell death upon COX (show COX8A Proteins) dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX (show COX8A Proteins) dysfunction.

  6. Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase (show ASAH1 Proteins) in a JNK (show MAPK8 Proteins)-dependent manner that is independent of CerS6 activity.

  7. CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.

  8. Upregulation of CERS6 in an experimental autoimmune encephalomyelitis model is sex dependent.

  9. Co-expression of CerS2 (show CERS2 Proteins) with CerS4 (show CERS4 Proteins)/CerS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  10. folate withdrawal also induced CerS6/C16-ceramide elevation accompanied by p53 (show TP53 Proteins) accumulation. Overall, these novel findings link folate and de novo ceramide pathways in cellular stress response.

Mouse (Murine) Ceramide Synthase 6 (CERS6) interaction partners

  1. CerS1 (show CERS1 Proteins), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Proteins)-null mice.

  2. CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.

  3. Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.

  4. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (show CERS1 Proteins)-Cers6) activity in macrophages is responsible for the accumulation of ceramide.

  5. CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.

  6. An important role is revealed for C16:0-Cer (show CBLN1 Proteins) (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.

  7. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6 (show ATF6 Proteins)-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2 (show CA2 Proteins)+ and ER/Golgi membrane network

Ceramide Synthase 6 (CERS6) Protein Profile

Protein Summary

May be involved in sphingolipid synthesis or its regulation (By similarity).

Gene names and symbols associated with Ceramide Synthase 6 Proteins (CERS6)

  • ceramide synthase 6 (LASS6)
  • ceramide synthase 6 (cers6)
  • LAG1 homolog, ceramide synthase 6 (LASS6)
  • ceramide synthase 6 (CERS6)
  • ceramide synthase 6 (Cers6)
  • 4732462C07Rik protein
  • AW544719 protein
  • CERS5 protein
  • CERS6 protein
  • Lass6 protein
  • RGD1561599 protein
  • si:ch211-278b7.1 protein
  • T1L protein

Protein level used designations for Ceramide Synthase 6 Proteins (CERS6)

LAG1 homolog, ceramide synthase 6 , lass6 , longevity assurance homolog 6 , LAG1 longevity assurance homolog 6

GENE ID SPECIES
100052305 Equus caballus
564867 Danio rerio
741293 Pan troglodytes
253782 Homo sapiens
241447 Mus musculus
366065 Rattus norvegicus
771503 Gallus gallus
488387 Canis lupus familiaris
100126279 Sus scrofa
616901 Bos taurus
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