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CLCN2 encodes a voltage-gated chloride channel. Additionally we are shipping Chloride Channel 2 Proteins (6) and many more products for this protein.
Showing 10 out of 67 products:
Human Polyclonal CLCN2 Primary Antibody for EIA, WB - ABIN951555
Scheper, van Berkel, Leisle, de Groot, Errami, Jentsch, Van der Knaap: Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cysts. in Genetic testing and molecular biomarkers 2010
Show all 5 references for ABIN951555
Human Monoclonal CLCN2 Primary Antibody for RNAi, ELISA - ABIN560397
Alessi, Andjelkovic, Caudwell, Cron, Morrice, Cohen, Hemmings: Mechanism of activation of protein kinase B by insulin and IGF-1. in The EMBO journal 1997
Show all 4 references for ABIN560397
Human Polyclonal CLCN2 Primary Antibody for ELISA, WB - ABIN4299049
Cornejo, Niemeyer, Zúñiga, Yusef, Sepúlveda, Cid: Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. in Journal of cellular physiology 2009
Human Monoclonal CLCN2 Primary Antibody for WB - ABIN394461
Ferrer, Corneo, Davis, Wan, Miyagishima, King, Maminishkis, Marugan, Sharma, Shure, Temple, Miller, Bharti: A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium. in Stem cells translational medicine 2014
Identification and characterization of the zebrafish ClC (show CLCF1 Antibodies)-2a/b/c chloride channel (show CLCA1 Antibodies) orthologs.
Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase (show ATP4b Antibodies), reduced tubulovesicles and reduced stimulated acid secretion.
Data indicate that membrane protein MLC1 is crucial for proper localization of adhesion molecule (show NCAM1 Antibodies) GlialCAM (show HEPACAM Antibodies) and chloride channel (show CLCA1 Antibodies) ClC-2, and for changing ClC-2 currents.
Loss of ClC-2 is associated with increased development of DSS (show PMP22 Antibodies)-induced colitis.
The PCR data revealed the existence of two astrocytic subpopulations markedly differing in their gene expression levels for inwardly rectifying K+ channels (Kir4.1 (show KCNJ10 Antibodies)), K(2P) channels (TREK-1 (show KCNK2 Antibodies) and TWIK-1 (show KCNK1 Antibodies)) and Cl- channels (ClC2).
ClC-2 channels are required for colonic electroneutral absorption of NaCl and KCl.
permeant Cl(-) ions contribute to V(m)-dependent gating of the broadly distributed ClC-2 Cl() channel.
GABAA (show GABRg1 Antibodies) receptor-mediated synaptic inputs from basket cells were modulated by ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
ClC-2 reduces barrier function in normal mucosa. Ultrastructural morphology of tight junctions and myosin light chain kinase (show MYLK Antibodies) appear to be important to the function of ClC-2 in normal mucosa.
these findings raise the possibility that ClC-2 expression plays a subtle neuroprotective role in the aging hippocampus
Heterozygous nmf240 mice present with a reduced electroretinography light peak component suggests that CLCN2 is necessary for the generation of this response component.
ClC-2-mediated intestinal Cl - secretion restores transepithelial resistance in ischemia-injured intestine.
Hyperpolarization activates CLC-2 mainly by driving intracellular anions into the channel pores.
The extracellular domain of GlialCAM (show HEPACAM Antibodies) is necessary for cell junction targeting and for mediating interactions with itself or with MLC1 and ClC-2.
both ubiquitous (AP-1A) and epithelium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 (show FOSB Antibodies) are capable of carrying out basolateral sorting of ClC-2.
SPAK (show STK39 Antibodies) and OSR1 (show OXSR1 Antibodies) are powerful negative regulators of the cell volume regulatory Cl- channel ClC-2
Correlation between CLC-2 gene expression and the cytoskeleton in human trabecular meshwork cells.
Our observations substantiate the concept that ClC-2 is involved in brain ion and water homoeostasis
JAK2 (show JAK2 Antibodies) down-regulates ClC-2 activity and thus counteracts Cl(-) exit, an effect which may impact on cell volume regulation
This study demonistrated that the first auxiliary subunit of ClC-2 and suggests that ClC-2 may play a role in the pathology of MLC disease.
ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of tight junction protein occludin (show OCLN Antibodies).
Sequence analysis of CLCN2 at genomic DNA and cDNA levels in 18 megalencephalic leukoencephalopathy MLC1 mutations revealed some nucleotide changes, but they were predicted to be nonpathogenic.
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
chloride channel 2
, novel protein similar to vertebrate chloride channel 2 (CLCN2)
, chloride channel protein 2
, PKA-activated chloride channel ClC-2G