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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Muscarinic Acetylcholine Receptor M2 Kits (53) and Muscarinic Acetylcholine Receptor M2 Proteins (6) and many more products for this protein.
Showing 10 out of 102 products:
Guinea Pig Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for Func, EIA - ABIN1108327
Fu, Gerd, Ake, Johan: Agonist-like activity of anti-peptide antibodies directed against an autoimmune epitope on the heart muscarinic acetylcholine receptor. in Receptors & channels 1994
Show all 3 references for ABIN1108327
Human Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for WB - ABIN658341
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
Human Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IF, ELISA - ABIN1535645
Bonner, Buckley, Young, Brann: Identification of a family of muscarinic acetylcholine receptor genes. in Science (New York, N.Y.) 1987
Dog (Canine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IF (p), IHC (p) - ABIN668646
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
cloning, characterization and expression patterns; results suggest that the M2 mAChR (show CHRM3 Antibodies) inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia
The M(2) muscarinic receptor (show CHRM5 Antibodies) plays a specific role in the initiation of hypoxic bradycardia in fish.
Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD (show ARCN1 Antibodies) patients.
Inactivation of M2 AChR/NF-kappaB (show NFKB1 Antibodies) signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.
CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.
This study demonstrated that CD4 (show CD4 Antibodies)+ and CD8 (show CD8A Antibodies)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.
The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha (show GNAO1 Antibodies) subunits in Escherichia coli.
CHRM2 but not CHRM1 (show CHRM1 Antibodies) or CHRM3 (show CHRM3 Antibodies) polymorphisms are associated with asthma susceptibility in Mexican patients.
High Muscarinic Receptor M2 expression is associated with peripartum cardiomyopathy.
[(3)H]LY2119620 to probe specifically the human M2 and M4 muscarinic receptor (show CHRM5 Antibodies) allosteric binding sites.
The present report found an association between genetic variation of the CHRM2 rs1824024 SNP in the 8-12 year old group and not in the older age groups.
This novel study demonstrated for the first time a full-scale screening of the proteomics research by CHRM2-C722G mutation and profiled 102 changed proteins, of which, eight might be critical in cardiac dysfunction
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Antibodies) and sling fibers similar to human clasp (show CLASRP Antibodies) and sling fibers.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC Antibodies)/protein (show HNRNPC Antibodies) kinase C (show PKC Antibodies) pathway
Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1 (show ADRB1 Antibodies)) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.
IL-17 (show IL17A Antibodies) production in the hearts of M2AChR mice is dependent on P2x7 (show P2RX7 Antibodies) expression in dilated cardiomyopathy.
Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Antibodies)-/- males and females, although only males exhibited a urinary phenotype.
These results demonstrate that M2R are dysfunctional and do not affect ACh levels in PRiMA knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.
Data indicate taht m2R-RGS6 (show RGS6 Antibodies)-IKACh pathway sets heart rate variability independently from the autonomic input.
M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (show ROCK2 Antibodies) (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG (show PRKG1 Antibodies) inhibitor H89.
M2 receptor is co-localized with VGLUT2 (show SLC17A6 Antibodies) on intraganglionic laminar endings of esophagus.
Presence of M2 mAChR (show CHRM3 Antibodies) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.
This study demonstrated that cholinergic projections recruit M(2) receptors to redistribute the gain of LTP (show SCP2 Antibodies) in CA3 (show CA3 Antibodies) pyramidal cells in an input-specific manner
The function of M2 MR is substituted by beta3-AR and that these effects are mediated via adenylyl cyclase rather than NOS (show NOS Antibodies).
enhanced tracheal contraction of the BK beta1 knockout can be ascribed to a defect in BK channel (show KCNMA1 Antibodies) opposition of M2 receptor-mediated contractions
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
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