Muscarinic Acetylcholine Receptor M2 antibody (AA 185-234)

Catalog No. ABIN1535645

The Rabbit Polyclonal anti-Muscarinic Acetylcholine Receptor M2 antibody (ABIN1535645) specifically detects Muscarinic Acetylcholine Receptor M2 in WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Muscarinic Acetylcholine Receptor M2 antibody (AA 185-234) (ABIN1535645)

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Muscarinic Acetylcholine Receptor M2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-Muscarinic Acetylcholine Receptor M2 Antibody

Binding Specificity: AA 185-234

Purpose: mAChR M2 Antibody

Specificity: MAChR M2 Polyclonal Antibody detects endogenous levels of mAChR M2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human CHRM2. AA range:185-234

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Muscarinic Acetylcholine Receptor M2

Target: Muscarinic Acetylcholine Receptor M2 (CHRM2) (Cholinergic Receptor, Muscarinic 2 (CHRM2))

Alternative Name: CHRM2

Background:

Synonyms: CHRM2, Muscarinic acetylcholine receptor M2

Background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Gene Name: CHRM2

Protein Name: Muscarinic acetylcholine receptor M2

Molecular Weight: 51 kDa

Gene ID: 1129

OMIM: 118493

UniProt: P08172