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May inhibits BMPs activity by blocking their interaction with their receptors. Additionally we are shipping CHRDL2 Kits (6) and CHRDL2 Proteins (5) and many more products for this protein.
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Human Polyclonal CHRDL2 Primary Antibody for WB - ABIN250700
Pisarska, Kuo, Bentsi-Barnes, Khan, Barlow: LATS1 phosphorylates forkhead L2 and regulates its transcriptional activity. in American journal of physiology. Endocrinology and metabolism 2010
Chl, like Chd (show CHRD Antibodies), dorsalizes embryos upon overexpression and is cleaved by BMP1 (show BMP1 Antibodies); loss-of-function experiments show Chl serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (show CHRD Antibodies) in forming the dorsoventral axis.
CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs
Differential expression of CHL2 variants was observed during myoblast and osteoblast differentiation, implying a role for this gene in these physiological processes.
CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs.
May inhibits BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
, chordin-like protein 2
, breast tumor novel factor 1
, chordin-related protein 2
, chordin like 2