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Chromosome 19 Open Reading Frame 40 Proteins (C19ORF40)

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Chromosome 19 Open Reading Frame 40 Antibodies (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C19ORF40 91442 Q9BTP7
C19ORF40 101831 Q8BHL6
C19ORF40 510793 Q2KHY5
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Top Chromosome 19 Open Reading Frame 40 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

C19ORF40 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

Cow (Bovine)

More Proteins for Chromosome 19 Open Reading Frame 40 (C19ORF40) Interaction Partners

Human Chromosome 19 Open Reading Frame 40 (C19ORF40) interaction partners

  1. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.

  2. Crystal structure of the FANCM-FAAP24 complex.

  3. Results show that the first HhH (show SLC25A15 Proteins) motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin.

  4. FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.

  5. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.

  6. FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA.

  7. FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity

  8. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM.

  9. DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia (show PALB2 Proteins).

Chromosome 19 Open Reading Frame 40 (C19ORF40) Protein Profile

Protein Summary

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007

Gene names and symbols associated with C19ORF40

  • chromosome 18 open reading frame, human C19orf40 (C18H19orf40)
  • chromosome 19 open reading frame 40 (C19orf40)
  • RIKEN cDNA C230052I12 gene (C230052I12Rik)
  • AW124591 protein
  • AW538696 protein
  • Faap24 protein

Protein level used designations for C19ORF40

Fanconi anemia-associated protein of 24 kDa , Fanconi anemia-associated protein, 24 kDa

GENE ID SPECIES
510793 Bos taurus
91442 Homo sapiens
101831 Mus musculus
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