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Chromosome 6 Open Reading Frame 134 Proteins (C6orf134)

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Additionally we are shipping Chromosome 6 Open Reading Frame 134 Antibodies (26) and Chromosome 6 Open Reading Frame 134 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C6orf134 79969 Q5SQI0
Rat C6orf134 C6orf134 361789 Q6MG11
C6orf134 73242 Q8K341
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Top Chromosome 6 Open Reading Frame 134 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,563.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,786.67
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,786.67
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,867.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details

C6orf134 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Chromosome 6 Open Reading Frame 134 (C6orf134) Interaction Partners

Human Chromosome 6 Open Reading Frame 134 (C6orf134) interaction partners

  1. Studies indicate that alpha-tubulin (show TUBA4A Proteins) acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6 (show HDAC6 Proteins)).

  2. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia.

  3. Data suggest that invariant residues Arg132 and Ser160 in catalytic domain of ATAT1 participate in stable interaction with CoA and acetyl-CoA (show LPCAT2 Proteins); ATAT1 with mutation at either residue exhibits much faster intracellular degradation.

  4. Crystal structure of the catalytic core of human MEC-17 in complex with acetyl-CoA (show LPCAT2 Proteins). MEC17 has large, conserved surface patch that is critical for enzymatic activity suggesting extensive interactions with alpha-tubulin (show TUBA4A Proteins).

  5. Mechanistic underpinnings for TAT (show TAT Proteins) activity and its preference for microtubules with slow turnover; cocrystal structures constrain TAT (show TAT Proteins) action to the microtubule lumen with Lys40 engaged in a suboptimal active site; despite the confined location of Lys40, TAT (show TAT Proteins) efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends.

  6. microtubules contacting clathrin-coated pits become acetylated by alphaTAT1; in migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis

  7. cysteine residues play important catalytic roles through a ternary complex mechanism. alphaTAT1 mutations have analogous effects on tubulin (show TUBB Proteins) acetylation in vitro and in cells

  8. analysis reveals a basic patch implicated in substrate binding and a conserved glutamine (show GFPT1 Proteins) residue required for catalysis, demonstrating that the family of alpha-tubulin (show TUBA4A Proteins) acetyltransferases uses a reaction mechanism different from other lysine acetyltransferases

Mouse (Murine) Chromosome 6 Open Reading Frame 134 (C6orf134) interaction partners

  1. alphaTAT1 has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.

  2. Data indicate that alpha-tubulin acetyltransferase 1 Atat1 is not required for survival and development but may regulate more advanced functions.

  3. Acetylation of alpha-tubulin (show TUBA4A Proteins) is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2 (show SIRT2 Proteins)) and HDAC6 (histone deacetylase 6 (show HDAC6 Proteins)). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells.

Zebrafish Chromosome 6 Open Reading Frame 134 (C6orf134) interaction partners

  1. Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.

Chromosome 6 Open Reading Frame 134 (C6orf134) Protein Profile

Protein Summary

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development (By similarity).

Gene names and symbols associated with C6orf134

  • chromosome 6 open reading frame 134 ortholog (C23H6orf134)
  • alpha tubulin acetyltransferase 1 (ATAT1)
  • alpha tubulin acetyltransferase 1 (Atat1)
  • alpha tubulin acetyltransferase 1 (atat1)
  • 0610011P08Rik protein
  • 2610008K08Rik protein
  • 2610110G12Rik protein
  • 3110080J08Rik protein
  • Alpha-TAT protein
  • C4H6orf134 protein
  • c6orf134 protein
  • C7H6ORF134 protein
  • C23H6orf134 protein
  • mec17 protein
  • Nbla00487 protein
  • RGD1303066 protein
  • TAT protein
  • wu:fj19c03 protein
  • zgc:65893 protein
  • zgc:77443 protein

Protein level used designations for C6orf134

hypothetical protein LOC615173 , acetyltransferase mec-17 homolog , alpha-TAT , alpha-tubulin N-acetyltransferase , Novel DUF738 containing protein (2610110G12Rik) , MEChanosensory abnormality homolog

GENE ID SPECIES
615173 Bos taurus
79969 Homo sapiens
361789 Rattus norvegicus
786491 Bos taurus
73242 Mus musculus
100144480 Sus scrofa
735057 Xenopus laevis
100141388 Macaca mulatta
406389 Danio rerio
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