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anti-Claudin 2 (CLDN2) Antibodies

CLDN2 product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Additionally we are shipping Claudin 2 Kits (33) and Claudin 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLDN2 9075 P57739
CLDN2 12738 O88552
CLDN2 300920  
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Top anti-Claudin 2 Antibodies at antibodies-online.com

Showing 10 out of 159 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CLDN2 (Human N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-CLDN2 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). CLDN2(arrow) was detected using the purified Pab (1:240 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB CLDN2 Antibody (C-term pTyr195) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLDN2 Antibody (C-term pTyr195) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of CLDN2 (arrow) using rabbit polyclonal CLDN2 Antibody (pTyr195) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CLDN2 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB CLDN2 Antibody (C-term pTyr224) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CLDN2 Antibody (C-term pTyr224) for immunohistochemistry. Clinical relevance has not been evaluated. Western blot analysis of CLDN2 (arrow) using rabbit polyclonal CLDN2 Antibody (pTyr224) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CLDN2 gene. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-CLDN2 Antibody (C-term) in mouse kidney tissue lysates (35ug/lane). CLDN2(arrow) was detected using the purified Pab (1:190 dilution). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-CLDN2 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-CLDN2-pY224 Antibody (ABIN390022) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-CLDN2 Antibody (N-term) (ABIN390291) in mouse heart tissue lysates (35 µg/lane). CLDN2(arrow) was detected using the purified polyclonal antibody (1:240 dilution). Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CLDN2 (Human N-term) (ABIN390291), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using Claudin 2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Claudin 2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-CLDN2 Antibody (C-term) (ABIN390292) in mouse kidney tissue lysates (35 µg/lane). CLDN2(arrow) was detected using the purified polyclonal antibody (1:190 dilution). 400 μL Log in to see 10 to 11 Days
$324.50
Details

CLDN2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Claudin 2 Antibodies

  1. Human Polyclonal CLDN2 Primary Antibody for EIA, IHC (p) - ABIN358848 : Morita, Furuse, Fujimoto, Tsukita: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 2 references for ABIN358848

  2. Human Polyclonal CLDN2 Primary Antibody for EIA, WB - ABIN358849 : Furuse, Fujita, Hiiragi, Fujimoto, Tsukita: Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. in The Journal of cell biology 1998 (PubMed)
    Show all 2 references for ABIN358849

  3. Human Polyclonal CLDN2 Primary Antibody for EIA, IHC (p) - ABIN951548 : Smith, Schacker, Reilly, Haase: A role for syndecan-1 and claudin-2 in microbial translocation during HIV-1 infection. in Journal of acquired immune deficiency syndromes (1999) 2010 (PubMed)
    Show all 2 references for ABIN951548

  4. Human Polyclonal CLDN2 Primary Antibody for EIA, WB - ABIN951547 : Kojima, Ishida, Takikita-Suzuki, Hotta, Katsura, Nagata, Enoki, Kato, Okabe: Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma. in Oncology reports 2010 (PubMed)
    Show all 2 references for ABIN951547

  5. Chicken Polyclonal CLDN2 Primary Antibody for WB - ABIN2775603 : Escaffit, Boudreau, Beaulieu: Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. in Journal of cellular physiology 2005 (PubMed)

More Antibodies against Claudin 2 Interaction Partners

Human Claudin 2 (CLDN2) interaction partners

  1. The authors conclude that claudin-2 forms gated paracellular channels.

  2. Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients.

  3. The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.

  4. Quercetin decreases claudin-2 expression mediated by up-regulation of miR-16 (show GDE1 Antibodies) expression and instability of claudin-2 mRNA in lung adenocarcinoma cells.

  5. Pan (show SUPT6H Antibodies)-inhibition of SFK signaling pathways elevated Claudin-2 expression levels in breast cancer cells. Loss of Yes or Fyn (show FYN Antibodies) induces Claudin-2 expression; whereas, diminished Lyn (show LYN Antibodies) levels impairs Claudin-2 expression in breast cancer cells.

  6. PKCiota binds to Rab14 (show RAB14 Antibodies) and that PKCiota requires Rab14 (show RAB14 Antibodies) for its correct distribution in cells. As with Rab14 (show RAB14 Antibodies), PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.

  7. Phosphorylation state of the tyrosine of claudin-1 (show CLDN7 Antibodies) and claudin-2 regulates interaction with ZO1 (show TJP1 Antibodies).

  8. TNF--alpha (show TNF Antibodies) modifies claudin-2 expression in tubular cells and this can have both short-term and long-term effects on transport and barrier functions.

  9. Claudin-5 (show CLDN5 Antibodies) overexpression promoted the interactions of claudin-1 (show CLDN7 Antibodies) and claudin-2 and enhanced the barrier function of retinal cells.

  10. Claudins 2 and 4 have reciprocal effects on epithelial barrier function, exhibit differential FRAP (show FRAP1 Antibodies) dynamics, and compete for residency within the tight junction.

Mouse (Murine) Claudin 2 (CLDN2) interaction partners

  1. The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.

  2. findings reveal a critical albeit complex role of claudin-2 in intestinal homeostasis by regulating epithelial permeability, inflammation and proliferation

  3. Based on studies of Cldn2(-/-) mice, claudin 2 regulates paracellular ion and water flow required for proper regulation of bile composition and flow.

  4. IL-6 (show IL6 Antibodies) modulation of intestinal TJ permeability was regulated by JNK (show MAPK8 Antibodies) activation of AP-1 (show JUN Antibodies) and AP-1 (show JUN Antibodies) activation of claudin-2 gene

  5. this study set out to map out all the pore-lining residues of claudin-2 by comprehensive cysteine-scanning mutagenesis of the entire first extracellular loop (ECL1).

  6. The capacity of non-AQP1 (show AQP1 Antibodies)-dependent transcellular proximal fluid reabsorption (PFR) is sufficient to be maintained in AQP1 (show AQP1 Antibodies)- and claudin-2-doubly deficient knockout mice.

  7. These results suggest that the ERK (show EPHB2 Antibodies) pathway positively regulates claudin-2 protein expression and claudin-2 is involved in lowering TER (show TECR Antibodies) in CMT93-II cells.

  8. Claudin-2 assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK (show MYLK Antibodies) in colon inflammation.

  9. cingulin (show CGN Antibodies) is dispensable for the structure and barrier function of tight junctions, and is embedded in signaling networks that control the expression of claudin-2.

  10. Together these data are consistent with phosphorylation at S208 playing a major role in the retention of claudin-2 at the plasma membrane

Claudin 2 (CLDN2) Antigen Profile

Protein Summary

This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Gene names and symbols associated with anti-Claudin 2 (CLDN2) Antibodies

  • claudin 2 (CLDN2) antibody
  • claudin 2 (cldn2) antibody
  • claudin 2 (Cldn2) antibody
  • AL022813 antibody
  • CLDN2 antibody
  • RGD1560247 antibody
  • zgc:92260 antibody

Protein level used designations for anti-Claudin 2 (CLDN2) Antibodies

claudin 2 , SP82 , claudin-2 , integral membrane protein claudin-2

GENE ID SPECIES
465795 Pan troglodytes
562525 Danio rerio
9075 Homo sapiens
12738 Mus musculus
422292 Gallus gallus
403649 Canis lupus familiaris
733684 Sus scrofa
404089 Bos taurus
300920 Rattus norvegicus
780475 Ovis aries
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