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Cleavage and Polyadenylation Specific Factor 6, 68kDa Proteins (CPSF6)

The protein encoded by CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. Additionally we are shipping CPSF6 Antibodies (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CPSF6 432508 Q6NVF9
CPSF6 11052 Q16630
Rat CPSF6 CPSF6 299811  
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Top CPSF6 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CPSF6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) Interaction Partners

Mouse (Murine) Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. Here we report that the CFIm subunits NUDT21/CPSF5 (show NUDT21 Proteins) and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells.

Human Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 (show PSIP1 Proteins) interaction drives integration into gene bodies.

  2. NUP153 (show NUP153 Proteins) and CPSF6 have overlapping binding sites, but each makes unique capsid monomers (CA) interactions. Multiple ligands share an overlapping interface in HIV-1 capsid that is lost upon viral disassembly.

  3. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

  4. study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo

  5. CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA).

  6. These results suggested that inhibition of HIV-1 by TNPO3 (show TNPO3 Proteins)-depleted cells requires CPSF6.

  7. Loss-of-function of CFIm68 and CFIm25 (show NUDT21 Proteins) leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells.

  8. TNPO3 (show TNPO3 Proteins) promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6.

  9. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly.

  10. A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid.

CPSF6 Protein Profile

Protein Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Gene names and symbols associated with CPSF6

  • cleavage and polyadenylation specific factor 6, 68kDa (CPSF6)
  • cleavage and polyadenylation specific factor 6, 68kDa (cpsf6)
  • cleavage and polyadenylation specific factor 6, 68kDa (LOC100220791)
  • cleavage and polyadenylation specific factor 6 (cpsf6)
  • cleavage and polyadenylation specific factor 6 (Cpsf6)
  • cleavage and polyadenylation specific factor 6, 68kDa (Cpsf6)
  • 4733401N12Rik protein
  • AI256641 protein
  • CFIM protein
  • CFIM68 protein
  • CPSF6 protein
  • HPBRII-4 protein
  • HPBRII-7 protein
  • wu:fa22f12 protein
  • zgc:85819 protein

Protein level used designations for CPSF6

cleavage and polyadenylation specific factor 6, 68kDa , cleavage and polyadenylation specificity factor subunit 6 , cleavage and polyadenylation specific factor 6, 68 kD subunit , CPSF 68 kDa subunit , cleavage and polyadenylation specificity factor 68 kDa subunit , cleavage factor Im complex 68 kDa subunit , pre-mRNA cleavage factor I, 68kD subunit , pre-mRNA cleavage factor Im (68kD) , pre-mRNA cleavage factor Im 68 kDa subunit , protein HPBRII-4/7

GENE ID SPECIES
452068 Pan troglodytes
446580 Xenopus laevis
548671 Xenopus (Silurana) tropicalis
100013834 Monodelphis domestica
100220791 Taeniopygia guttata
100589466 Nomascus leucogenys
327069 Danio rerio
432508 Mus musculus
417844 Gallus gallus
11052 Homo sapiens
474441 Canis lupus familiaris
100152191 Sus scrofa
768231 Bos taurus
299811 Rattus norvegicus
100174771 Pongo abelii
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