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Coagulation Factor II (thrombin) Receptor-Like 1 Proteins (F2RL1)

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. Additionally we are shipping F2RL1 Kits (34) and F2RL1 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
Rat F2RL1 F2RL1 116677 Q63645
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Top F2RL1 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

F2RL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Data suggest that thrombin (show F2 Proteins) can directly activate PAR2 vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Proteins) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Proteins) and 2).

  2. Activation of PAR-2 by SLIGRL, a PAR-2 specific ligand, leads to dual phosphorylation of both catalytic sites but primarily regulated eNOS (show NOS3 Proteins)-Thr (show TRH Proteins)-495 phosphorylation with no change in nitric oxide production.

  3. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Proteins) signaling, resulting in RelA (show NFkBP65 Proteins) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  4. This study provides evidence for the major role of PAR-2 in the pathogenesis of gastroesophageal reflux disease (GERD) and GERD-associated mucosal alterations.

  5. PAR-2 expression is increased on CD14 (show NDUFA2 Proteins)++CD16 (show CD16 Proteins)+ monocytes in the peripheral blood of subjects with severe asthma and may be a biomarker of asthma severity.

  6. PAR-2 contributes to the progression of pulmonary fibrosis, and targeting PAR-2 may be a promising therapeutic strategy for treating pulmonary fibrosis.

  7. Binding of the PH domain of PAR-2 enables breast cancer growth and extravillous trophoblast invasion.

  8. Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 (show MARK2 Proteins) and PAR-2) associate with breast cancer outcome in an estrogen receptor (ER (show ESR1 Proteins))-dependent manner.

  9. Results show that exposure of bronchial epithelial cells to Aspergillus fumigatus extract suppressed poly I:C and HRV16 signaling via a mechanism shown to involve activation of PAR-2 and PTPN11 (show PTPN11 Proteins).

  10. alpha-Enolase (show ENO1 Proteins) increases after injury and may activate pulmonary endothelial cells and prime PMNs through plasmin (show PLG Proteins) activity and PAR-2 activation

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  2. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 Proteins) signaling, resulting in RelA (show NFkBP65 Proteins) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  3. Tryptase (show TPSAB1 Proteins) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (show OVA Proteins)-induced atopic-like dermatitis

  4. This study reveals, for the first time, an important role for PAR2 in allergic lung inflammation

  5. HAI-1 (show SPINT1 Proteins) may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase (show MAPK14 Proteins) signaling.

  6. PAR2 activation through endogenous mast cell tryptase activity could be required, at least partially, to mediate CCL11-induced eosinophil migration

  7. These studies identify the thrombin receptor (show F2R Proteins) as a powerful extracellular regulatory switch that could be readily targeted to improve myelin production in the face of white matter injury and disease.

  8. PAR2 knockout prevented bone cancer-related pain behaviours and associated neurochemical changes in dorsal root ganglion and dorsal horn.

  9. TR deficiency inhibits osteoclastogenesis by decreasing RANKL/OPG (show TNFSF11 Proteins) ratio, resulting in a high bone mass phenotype

  10. These findings indicate that hematopoietic TF-PAR2 signaling plays a pivotal role in the hepatic inflammatory responses, steatosis, and hepatic insulin (show INS Proteins) resistance that lead to systemic insulin (show INS Proteins) resistance and type 2 diabetes in obesity.

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Protein Profile

Protein Summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Gene names and symbols associated with F2RL1

  • Proteinase-activated receptor 2 (par2)
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1)
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1)
  • Gpcr11 protein
  • GPR11 protein
  • Par-2 protein
  • Par2 protein

Protein level used designations for F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

GENE ID SPECIES
100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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