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The protein encoded by Coq7 is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Additionally we are shipping Coq7 Proteins (8) and many more products for this protein.
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Human Polyclonal Coq7 Primary Antibody for ELISA - ABIN1999613
Ewbank, Barnes, Lakowski, Lussier, Bussey, Hekimi: Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. in Science (New York, N.Y.) 1997
Show all 5 references for ABIN1999613
Human Monoclonal Coq7 Primary Antibody for ELISA - ABIN1999611
Martin, Han, Gordon, Terry, Prabhakar, She, Xie, Hellsten, Chan, Altherr, Couronne, Aerts, Bajorek, Black, Blumer, Branscomb, Brown, Bruno, Buckingham, Callen, Campbell, Campbell, Campbell, Caoile et al.: The sequence and analysis of duplication-rich human chromosome 16. ... in Nature 2004
Show all 5 references for ABIN1999611
Caenorhabditis elegans (C. elegans) Polyclonal Coq7 Primary Antibody for WB - ABIN93561
Arroyo, Santos-Ocaña, Ruiz-Ferrer, Padilla, Gavilán, Rodríguez-Aguilera, Navas: Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans. in FEBS letters 2006
Mitochondrial COQ9 (show COQ9 Antibodies) is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.
action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1 (show CDK11B Antibodies).
The siRNA-mediated knock down leads to an increase in cytoplasmic superoxide dismutase (SOD1 (show SOD1 Antibodies)) mRNA levels and activity
These findings indicate that MCLK1 (also known as Coq7) regulates both coenzyme Q synthesis and distribution within mitochondrial membranes.
CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.
clk-1 deficiency induces apoptosis associated with mitochondrial dysfunction in mouse embryos.
action of clioquinol on several age-dependent neurodegenerative diseases with distinct etiologies might result from a slowing down of the aging process through action of the drug on CLK-1.
Reduction in COQ7 levels gradually prevents the deterioration of mitochondrial function and associated increase of global oxidative stress that is normally observed in Sod2 (show SOD2 Antibodies)(+/-) mutants.
Nuclear CLK-1 mediates a retrograde signalling pathway that is conserved from Caenorhabditis elegans to humans and is responsive to mitochondrial reactive oxygen species, thus acting as a barometer of oxidative metabolism.
no measurable intrinsic ETC defect exists in clk-1 mitochondria. The data indicate that DMQ(9) specifically inhibits electron transfer from complex I to ubiquinone.
Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD.
Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1.
Caenorhabditis elegans clk-1 mutants are sensitive to ubiquinone side-chain length
in maternally resqued animals, the effect of clk-1 mutations on adult lifespan in uncoupled from their effects on development and reproduction
differential fertility of clk-1 mutant nematodes fed Q isoforms may result from changes in Q localization, altered recognition by Q-binding proteins, and/or potential defects in mitochondrial function resulting from the mutant CLK-1 polypeptide itself.
Suppressors of the missense mutation of clk-1 were identified; each mutant suppresses a different subset of phenotypes.
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.
COQ7 coenzyme Q, 7 homolog ubiquinone
, coenzyme Q biosynthesis protein 7 homolog
, placental protein KG-20
, timing protein clk-1 homolog
, ubiquinone biosynthesis protein COQ7 homolog
, Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7
, demethyl-Q 7