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Collagen, Type XVII, alpha 1 Proteins (COL17A1)

COL17A1 encodes the alpha chain of type XVII collagen. Additionally we are shipping COL17A1 Antibodies (37) and COL17A1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat COL17A1 COL17A1 294027  
COL17A1 1308 Q9UMD9
COL17A1 12821 Q07563
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Top COL17A1 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

COL17A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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More Proteins for Collagen, Type XVII, alpha 1 (COL17A1) Interaction Partners

Human Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. R1303Q in COL17 hampers C-terminal cleavage of COL17. Increase in remnants of non-cleaved COL17 ectodomain in extracellular matrix (ECM (show MMRN1 Proteins)) induces aberrant laminin 332 deposition in ECM (show MMRN1 Proteins), which may be associated with disorganized basement membrane formation.

  2. The COL17A1 c.3156C-->T variant is the likely causative mutation in our recurrent corneal erosion families, and its presence in 4 independent families suggests that it is prevalent in epithelial recurrent erosion dystrophy.

  3. Elevated serum levels of BP180 antibodies in the first trimester of pregnancy precede gestational pemphigoid and remain elevated for a long time after remission of the disease.

  4. Letter/Case Report: IgE BP180 antibodies contribute to the occurrence of urticarial erythema in bullous pemphigoid (show DST Proteins) patients.

  5. IgE anti-BP180 autoantibody level is increased in some Chinese patients with bullous pemphigoid (show DST Proteins).

  6. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

  7. Our findings implicate presumed gain-of-function COL17A1 mutations causing dominantly inherited ERED and improve understanding of the underlying pathology.

  8. Case Reports: two Japanese patients with bullous pemphigoid (show DST Proteins) with only BP230 (show DST Proteins) autoantibodies detected by ELISA.

  9. Circulating anti-BP180 autoantibodies are not correlated with severity of genital lichen sclerosis or itching.

  10. Variants of the PTCH1 (show PTCH1 Proteins) and COL17A1 genes may contribute to the development of Ossification of the posterior longitudinal ligament.

Mouse (Murine) Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

  2. The deletion of the bullous pemphigoid (show DST Proteins) epitope region of collagen XVII induces blistering, autoimmunization, and itching in a mouse disease model.

  3. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2 (show LAMC2 Proteins)(jeb) mice

  4. These results provide mechanistic evidence that ColXVII coordinates keratinocyte adhesion and directed motility by interfering integrin dependent PI3K activation and by stabilizing lamellipodia

  5. Neutrophil elastase (show ELANE Proteins) cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid (show DST Proteins)

  6. Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of hair follicle stem cells through maintaining their quiescence and immaturity.

  7. bullous pemphigoid antigen 2 has a role in eliciting specific IgG and the immune responses arising in epidermolysis bullosa

  8. ADAM9 (show ADAM9 Proteins) and ADAM10 (show ADAM10 Proteins) can both contribute to collagen XVII shedding in skin.

Cow (Bovine) Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. results show that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease (show ADAM8 Proteins) and suggest involvement of the cleavage in hemidesmosomal disassembly(bullous pemphigoid antigen 180/type XVII collagen)

COL17A1 Protein Profile

Protein Summary

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Gene names and symbols associated with COL17A1

  • collagen, type XVII, alpha 1 (Col17a1)
  • collagen, type XVII, alpha 1b (col17a1b)
  • collagen, type XVII, alpha 1 (COL17A1)
  • BA16H23.2 protein
  • BP180 protein
  • BPA-2 protein
  • Bpag protein
  • Bpag2 protein
  • COL17A1 protein
  • fk89a06 protein
  • LAD-1 protein
  • si:ch211-223p8.6 protein
  • wu:fk89a06 protein

Protein level used designations for COL17A1

collagen alpha-1(XVII) chain , procollagen, type XVII, alpha 1 , col17a1a , collagen, type XVII, alpha 1 , collagen alpha-1(XVII) chain-like , 180 kDa bullous pemphigoid antigen 2 , alpha 1 type XVII collagen , bA16H23.2 (collagen, type XVII, alpha 1 (BP180)) , bullous pemphigoid antigen 2 (180kD) , collagen XVII, alpha-1 polypeptide , bullous pemphigoid antigen 2 , bullous pemphigoid antigen 180 , novel collagen protein , Collagen alpha-1(XVII) chain , bullous pemphigoid autoantigen 2 , Bullous pemphigoid antigen 2 , collagen type XVII

GENE ID SPECIES
294027 Rattus norvegicus
568794 Danio rerio
100452122 Pongo abelii
100069671 Equus caballus
100604365 Nomascus leucogenys
1308 Homo sapiens
12821 Mus musculus
513804 Bos taurus
396503 Gallus gallus
403739 Canis lupus familiaris
101843802 Mesocricetus auratus
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