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anti-Crystallin, alpha B (CRYAB) Antibodies

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping Crystallin, alpha B Kits (49) and Crystallin, alpha B Proteins (33) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRYAB 1410 P02511
CRYAB 12955 P23927
CRYAB 25420 P23928
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Top anti-Crystallin, alpha B Antibodies at antibodies-online.com

Showing 10 out of 400 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of CRYAB (arrow) using rabbit polyclonal CRYAB A... CRYAB Antibody (Center)  western blot analysis in mouse lung tissue ly... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with anisomy... Immunohistochemistry analysis of paraffin-embedded human heart, using ... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human skeletal musc... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells treated with nocoda... Immunohistochemistry analysis of paraffin-embedded human skeletal musc... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Cow Mouse Un-conjugated ELISA, WB Alpha B Crystallin (1A7 D5), AlphaA (L), AlphaB (R). 50 μg Log in to see 3 to 4 Days
$202.40
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human heart tissue,... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from 293 cells, using CRYAB (Ab-19) ... Immunohistochemistry analysis of paraffin-embedded human skeletal musc... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Goat Un-conjugated ELISA, WB ABIN238599 (0.01µg/ml) staining of mouse eye lysate (35µg protein in R... 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Mouse Un-conjugated WB CRYAB monoclonal antibody (M01), clone 1A10-1A4 Western Blot analysis ... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB 400 μL Log in to see 10 to 11 Days
$324.50
Details

CRYAB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Crystallin, alpha B Antibodies

  1. Cow (Bovine) Monoclonal CRYAB Primary Antibody for ELISA, WB - ABIN361808 : Bullard, Ferguson, Minajeva, Leake, Gautel, Labeit, Ding, Labeit, Horwitz, Leonard, Linke: Association of the chaperone alphaB-crystallin with titin in heart muscle. in The Journal of biological chemistry 2004 (PubMed)
    Show all 13 references for ABIN361808

  2. Human Monoclonal CRYAB Primary Antibody for WB - ABIN393435 : Kida, Wierzba-Bobrowicz, Palminiello, Kaur, Jarzabek, Walus, Albertini, Golabek: Molecular chaperone alphaB-crystallin is expressed in the human fetal telencephalon at midgestation by a subset of progenitor cells. in Journal of neuropathology and experimental neurology 2010 (PubMed)
    Show all 5 references for ABIN393435

  3. Human Monoclonal CRYAB Primary Antibody for WB - ABIN1944889 : Kramps, de Man, de Jong: The primary structure of the B2 chain of human alpha-crystallin. in FEBS letters 1977 (PubMed)
    Show all 4 references for ABIN1944889

  4. Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1532588 : Dubin, Ally, Chung, Piatigorsky: Human alpha B-crystallin gene and preferential promoter function in lens. in Genomics 1990 (PubMed)
    Show all 2 references for ABIN1532588

  5. Human Polyclonal CRYAB Primary Antibody for IHC, ELISA - ABIN1531572 : Kovalyov, Shishkin, Efimochkin, Kovalyova, Ershova, Egorov, Musalyamov: The major protein expression profile and two-dimensional protein database of human heart. in Electrophoresis 1996 (PubMed)
    Show all 2 references for ABIN1531572

  6. Human Polyclonal CRYAB Primary Antibody for ELISA, WB - ABIN238599 : Ousman, Tomooka, van Noort, Wawrousek, OConnor, Hafler, Sobel, Robinson, Steinman: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. in Nature 2007 (PubMed)

  7. Human Polyclonal CRYAB Primary Antibody for IHC (p), WB - ABIN657620 : Martins-de-Souza, Schmitt, Röder, Lebar, Schneider-Axmann, Falkai, Turck: Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. in Journal of psychiatric research 2010 (PubMed)

More Antibodies against Crystallin, alpha B Interaction Partners

Pig (Porcine) Crystallin, alpha B (CRYAB) interaction partners

  1. This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.

Human Crystallin, alpha B (CRYAB) interaction partners

  1. alpha B crystallin is an independent prognostic factor of infiltrating ductal carcinoma of the breast

  2. two novel missense mutations, p.R11C and p.R12C, in CRYAB associated with autosomal recessive congenital nuclear cataracts.

  3. Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin (show CRYBA1 Antibodies).

  4. Phosphorylation of alphaB-crystallin has dual role that manifests either beneficial or deleterious consequences depending on the extent of phosphorylation and interaction with cytoskeleton. [review]

  5. The multifunctional activity of human alphaB crystallin results from the interactive peptide sequences exposed on the surface of the molecule. [review]

  6. Data show that phosphorylation of crystallin alphaB (cryAB) deters its packaging into vesicles for exosomal secretion.

  7. CRYAB protein was up regulated in laryngeal squamous cell carcinoma.

  8. was It is markedly upregulated in the substantia nigra of PD patients where Cryab was present in glial cell inclusions.

  9. A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.

  10. These data suggest that alphaB-crystallin uses its inherent structural plasticity to expose distinct binding interfaces and thus interact with a wide range of structurally variable clients.

Mouse (Murine) Crystallin, alpha B (CRYAB) interaction partners

  1. It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Antibodies)-mediated maintenance of whole body homeostasis.

  2. A previously unrecognized link between c-Jun (show JUN Antibodies) and Nrf2 (show NFE2L2 Antibodies) transcription factors and redox-induced CRYAB expression in muscle cells.

  3. CryAB protects decidualization against stress conditions.

  4. TNF-alpha (show TNF Antibodies)-induced endothelial adhesion molecule (show NCAM1 Antibodies) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.

  5. Study shows that overexpression of Bcl-2 (show BCL2 Antibodies) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (show BCL2 Antibodies) hearts.

  6. alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (show TGFB1 Antibodies) pathway via its role in modulating the cellular localization of Smad4 (show SMAD4 Antibodies).

  7. Data suggest that Cryab plays role in embryo implantation/decidualization; on day 5 of pregnancy when embryo implantation takes place, high level of Cryab mRNA is expressed in subluminal stroma surrounding the implanting blastocyst.

  8. Alpha B-crystallin inhibits caspase 3 activation in cells primed for apoptosis by retinoblastoma protein inactivation.

  9. data collectively demonstrate that alphaB crystallin provides critical protection of mitochondrial function during endoplasmic reticulum stress-induced retinal pigment epithelial apoptosis

  10. astrocytic DRD2 (show DRD2 Antibodies) activation normally suppresses neuroinflammation in the central nervous system through a CRYAB-dependent mechanism

Cow (Bovine) Crystallin, alpha B (CRYAB) interaction partners

  1. The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.

  2. In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH (show GAPDH Antibodies) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

  3. one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (show NEU2 Antibodies) resistance to disassembly

  4. The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.

Crystallin, alpha B (CRYAB) Antigen Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy.

Gene names and symbols associated with CRYAB

  • crystallin, alpha B (CRYAB) antibody
  • hypothetical protein (alpha-B-crystallin) antibody
  • crystallin, alpha B (Cryab) antibody
  • AACRYA antibody
  • CMD1II antibody
  • Crya-2 antibody
  • Crya2 antibody
  • CRYAB antibody
  • CTPP2 antibody
  • CTRCT16 antibody
  • HspB5 antibody
  • MFM2 antibody

Protein level used designations for CRYAB

crystallin, alpha B , alpha-crystallin B chain , hypothetical protein , heat shock protein beta-5 , heat-shock 20 kD like-protein , renal carcinoma antigen NY-REN-27 , rosenthal fiber component , P23 , alpha B-crystallin , alpha(B)-crystallin , crystallin, alpha 2 , crystallin, alpha polypeptide 2 , Crystallin, alpha polypeptide 2 , Alpha(B)-crystallin , Alpha-crystallin B chain , alpha B crystallin , alpha-B-crystallin , alphaB-crystallin

GENE ID SPECIES
451543 Pan troglodytes
710747 Macaca mulatta
791109 Ornithorhynchus anatinus
100127443 Sus scrofa
191528 Caenorhabditis elegans
1410 Homo sapiens
12955 Mus musculus
281719 Bos taurus
25420 Rattus norvegicus
396089 Gallus gallus
100519789 Sus scrofa
497274 Ovis aries
100009295 Oryctolagus cuniculus
100306972 Cavia porcellus
479441 Canis lupus familiaris
101827485 Mesocricetus auratus
100172850 Pongo abelii
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