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Cullin-Associated and Neddylation-Dissociated 1 Proteins (CAND1)

Enhances transcription from various types of promoters. Additionally we are shipping CAND1 Antibodies (38) and CAND1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CAND1 71902 Q6ZQ38
CAND1 55832 Q86VP6
Rat CAND1 CAND1 117152 P97536
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Top CAND1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CAND1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Cullin-Associated and Neddylation-Dissociated 1 (CAND1) Interaction Partners

Mouse (Murine) Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

Human Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 (show COPS8 Proteins) signalosome (CSN), neddylated cullin 3 (Cul3 (show CUL3 Proteins)) and the BTB protein Keap1 (show KEAP1 Proteins).

  2. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1.

  3. We demonstrate that the accumulation of p27 (show PAK2 Proteins) is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 (show PAK2 Proteins) and blocks adipogenesis.

  4. Study shows that Cand1 can unambiguously stimulate SCF (show KITLG Proteins) activity in vitro by enabling an F box protein-Skp1 (show SKP1 Proteins) complex to access Cul1 (show CUL1 Proteins) that was previously occupied by a different F box protein-Skp1 (show SKP1 Proteins) complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 (show CUL1 Proteins) molecules.

  5. CAND1 promotes PLK4 (show PLK4 Proteins)-mediated centriole overduplication and is frequently disrupted in prostate cancer.

  6. COMMD1 (show COMMD1 Proteins) (copper metabolism MURR1 (show COMMD1 Proteins) domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

  7. CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms

  8. miR (show MLXIP Proteins)-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.

  9. selectively binds to unneddylated CUL1 (show CUL1 Proteins) and is dissociated by CUL1 (show CUL1 Proteins) neddylation

  10. binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex

Arabidopsis thaliana Cullin-Associated and Neddylation-Dissociated 1 (CAND1) interaction partners

  1. HVE/CAND1 gene acts upstream of ATHB-8 at least in higher order veins, in a pathway that involves AXR1, but not LOP1, PIN1, CVP1 or CVP2.

  2. The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.

CAND1 Protein Profile

Protein Summary

Enhances transcription from various types of promoters. Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins (By similarity).

Gene names and symbols associated with CAND1

  • cullin-associated and neddylation-dissociated 1 (CAND1)
  • cullin-associated and neddylation-dissociated 1 (cand1)
  • cullin associated and neddylation disassociated 1 (Cand1)
  • cullin-associated and neddylation-dissociated 1 (Cand1)
  • cullin-associated NEDD8-dissociated protein 1 (CAND1)
  • 2310038O07Rik protein
  • 6330512O03Rik protein
  • AI195005 protein
  • AI846556 protein
  • ATCAND1 protein
  • cand2 protein
  • cullin-associated and neddylation dissociated protein
  • CULLIN-ASSOCIATED AND NEDDYLATION DISSOCIATED 1 protein
  • D10Ertd516e protein
  • ETA2 protein
  • fb78a05 protein
  • HEMIVENATA protein
  • HVE protein
  • mKIAA0829 protein
  • T8K22.14 protein
  • T8K22_14 protein
  • Tip120 protein
  • Tip120A protein
  • Tp120a protein
  • wu:fb78a05 protein
  • zgc:55729 protein

Protein level used designations for CAND1

cullin-associated and neddylation-dissociated 1 , cullin-associated and neddylation-dissociated 2 (putative) , TIP120 protein , cullin-associated NEDD8-dissociated protein 1 , cullin-associated and neddylation-dissociated protein 1 , p120 CAND1 , cullin-associated NEDD8-dissociated protein 1-like , TBP-interacting protein , TBP interacting protein , TBP-interacting protein 120A , TBP-interacting protein of 120 kDa A , TBP-interacting protein TIP120A , cullin associated and neddylation disassociated 1

GENE ID SPECIES
417837 Gallus gallus
447973 Xenopus (Silurana) tropicalis
452060 Pan troglodytes
100159824 Acyrthosiphon pisum
100173509 Pongo abelii
100177977 Ciona intestinalis
100202560 Hydra magnipapillata
100347974 Oryctolagus cuniculus
100386203 Callithrix jacchus
100485277 Xenopus (Silurana) tropicalis
100543082 Meleagris gallopavo
71902 Mus musculus
55832 Homo sapiens
117152 Rattus norvegicus
443799 Xenopus laevis
406806 Danio rerio
474437 Canis lupus familiaris
538086 Bos taurus
814786 Arabidopsis thaliana
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