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Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Additionally we are shipping CDK14 Antibodies (77) and many more products for this protein.
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Knockdown of PFTK1 inhibited the proliferation and invasion of pancreatic cancer cells as well as the EMT (show ITK Proteins) progress by suppressing the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway.
PFTK1 overexpression promoted proliferation, migration and invasion of gastric cancer cells, while PFTK1 knockdown led to the opposite results.
Knockdown of PFTK1 increases E-cadherin (show CDH1 Proteins) expression, decreases vimentin (show VIM Proteins) expression and inhibits migration of glioma cells.
Up-regulated PFTK1 might promote breast cancer progression.
Cigarette smoke down regulates CDK14 levels and impairs Wnt (show WNT2 Proteins) signaling.
findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 (show MARK3 Proteins) and PFTK1
binding of CCNY (show CCNY Proteins) to 14-3-3 (show YWHAQ Proteins) significantly enhanced the association between CCNY (show CCNY Proteins) and CDK14
Human cyclin Y (CCNY (show CCNY Proteins)) is a phosphoprotein in vivo and phosphorylation of CCNY (show CCNY Proteins) by CDK14 triggers its ubiquitination and degradation.
in patients with oesophageal squamous cell carcinoma 5-year overall survival rate was poorer in patients positive for PFTK1 than those with negative expression; uni- and multivariate analyses identified PFTK1 as an independent marker of prognosis
Taken together, our data propose a novel, oncogene (show RAB1A Proteins)-tumor suppressor interplay, where oncogenic PFTK1 confers HCC (show FAM126A Proteins) cell motility through inactivating the actin-binding motile suppressing function of TAGLN2 (show TAGLN2 Proteins) via phosphorylation.
may be a key regulator for thyrotropin-releasing hormone (TRH (show TRH Proteins)) action in the cerebellum through the NO-cGMP pathway
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
PFTAIRE protein kinase 1
, cell division protein kinase 14
, serine/threonine-protein kinase PFTAIRE-1
, Cell division protein kinase 14