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The protein encoded by CDK20 contains a kinase domain most closely related to the cyclin-dependent protein kinases. Additionally we are shipping Cyclin-Dependent Kinase 20 Antibodies (89) and Cyclin-Dependent Kinase 20 Kits (1) and many more products for this protein.
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A CCRK-EZH2 (show EZH2 Proteins) epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patient.
In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK (show ICK Proteins) and an ICK (show ICK Proteins)-related kinase MAK (show MAK Proteins), thereby inhibiting glioblastoma cell proliferation.
Data indicate that expression of ERAS, LHX1 (show LHX1 Proteins), and CCRK is increased in aggressive subgroups of medulloblastomas.
Cell cycle-related kinase is a direct androgen receptor (show AR Proteins)-regulated gene that drives beta-catenin (show CTNNB1 Proteins)/T cell factor-dependent hepatocarcinogenesis
results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2 (show CDK2 Proteins), cyclin E (show CCNE1 Proteins) and Rb.
identification of p42 (show EPB42 Proteins), a novel cyclin-dependent kinase (show CDK1 Proteins)-activating kinase (CAK (show CCNH Proteins)) activity in human cells; p42 (show EPB42 Proteins) is essential for the phosphorylation of Thr (show TRH Proteins)-160 and activation of CDK2 (show CDK2 Proteins) and is indispensable for cell growth
Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point.
Overexpression of CCRK is associated with ovarian carcinoma.
heart expresses a splice variant of CCRK, which promotes cardiac cell growth and survival; differs from the generic isoform in protein-protein interactions, substrate specificity and regulation of cell cycle; and is down-regulated in heart failure
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, CDK-activating kinase p42
, cell cycle-related kinase
, cell division protein kinase 20
, cyclin-dependent protein kinase H
, cyclin-kinase-activating kinase p42
, CDK-related protein kinase PNQLARE
, cell cycle related kinase
, cell cycle-related kinase cardiac