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The protein encoded by CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. Additionally we are shipping CDK10 Antibodies (91) and CDK10 Kits (1) and many more products for this protein.
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cdk10 has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a (show RAF1 Proteins) expression
CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays.
CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 (show PKN2 Proteins) and promotion of RhoA (show RHOA Proteins) signaling.
Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival
Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10.
Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC (show NPC1 Proteins)) patients.
CDK10/cyclin M (show CCNL2 Proteins) is a protein kinase (show CDK7 Proteins) that controls ETS2 (show ETS2 Proteins) degradation and is deficient in STAR syndrome.
Data show that peptidyl-prolyl isomerase Pin1 sil (show PIN1 Proteins)encing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression.
CDK10 plays a crucial role in the growth and survivability of biliary tract cancer.
reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression
CDK10 is not a target for aberrant DNA methylation (show HELLS Proteins) in breast cancer.
Data indicate that peptidyl-prolyl isomerase Pin1 (show PIN1 Proteins)(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1 (show PIN1 Proteins)(+/+) MEFs.
Data show that murine cdk10 binds Ets2 (show ETS2 Proteins) transcription factors in vitro, does not show a direct involvement in the G2/M transition and, therefore, does not affect the proliferation rate of the cell lines analyzed.
Discusses PISSLRE, the human ortholog of mouse cyclin-dependent kinase 10.
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene.
cell division protein kinase 10
, PITSLRE subfamily protein kinase
, protein kinase, CMGC group
, cyclin-dependent kinase 10
, cell division protein kinase 10-like
, cyclin-dependent kinase (CDC2-like) 10
, hypothetical protein
, CDC2-related protein kinase
, cyclin-dependent kinase related protein
, serine/threonine protein kinase PISSLRE
, serine/threonine-protein kinase PISSLRE
, cyclin dependent kinase 10