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Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins (CYP19A1)

CYP19A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Antibodies (150) and Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Kits (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP19A1 1588 P11511
CYP19A1 25147  
CYP19A1 13075 P28649
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Top Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,443.00
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
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CYP19A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Interaction Partners

Pig (Porcine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. P450arom was expressed in all layers of the arterial and venous vessels of the spermatic cord with higher intensity of staining in June long daylight) compared to December(short daylight).

  2. Decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR (show MYLIP Proteins)-378 regulates the maturation of cumulus-oocyte complexes.

  3. show that micro-RNA378 (miR (show MYLIP Proteins)-378) is spatiotemporally expressed in porcine granulosa cells, the cells that generate estradiol in the ovary during follicular development, in an inverse manner compared with the expression of aromatase

  4. Pig ejaculated spermatozoa express aromatase.

  5. The presence of aromatase and 11beta-HSD 2 (show HSD11B2 Proteins) in Leydig cells increased, together with germ and Sertoli cell numbers.

  6. This study demonstrates that transferrin (show Tf Proteins) had a dose-dependent inhibitory effect on follicle stimulating hormone-stimulated aromatase activity.

Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. EGb 761 reduced the tumor size and significantly reduced tumor CYP19 mRNA expression.

  2. The CT genotype of the rs2289105 polymorphism in the CYP19 gene is associated with a decreased risk of CHD (show CHDH Proteins) and may be a genetic marker of protection from CHD (show CHDH Proteins)

  3. Metformin inhibits PGE2-induced CYP19A1 mRNA expression/aromatase activity via AMPK (show PRKAA1 Proteins) activation in endometriotic stromal cells.

  4. Higher CYP19A1 expression and E2 concentrations are associated with increased risk of endometrial cancer.

  5. study to determine distribution of CYP19(TTTA)n polymorphism in Mexican general population and search for associations of particular genotypes with hip fracture and lumbar spine osteoporosis; the A1 allele and the A1A1 genotype were associated with an elevated risk of fracture; the A2 allele was associated with protection of hip fracture as the A2A2 genotype

  6. The leptin (show LEP Proteins), ObR (show LEPR Proteins) and aromatase protein expression levels were increased in lesions in the vaginal septum and were decreased in the intestine lesions

  7. The CYP19A1 rs10046 polymorphism is associated with cardiovascular risk factors such as circulating apoB (show APOB Proteins), insulin (show INS Proteins) resistance and hypertension in a sex- and obesity-specific manner.

  8. The rs6493497 and rs7176005 SNPs of the CYP19A1 gene may be genetic markers that influence the risk of FPHL in this Chinese population.

  9. the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated.

  10. Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.

Cow (Bovine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. in granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons

  2. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  3. This study evaluated the relationships among aromatase, IGF-1 (show IGF1 Proteins), IGF2R (show IGF2R Proteins), and FSH (show BRD2 Proteins) levels expressed in ovarian follicles of cattle selected for twin pregnancies.

  4. Data indicated de novo DNA methylation (show HELLS Proteins) fter the luteinizing hormone-induced down-regulation of CYP19A1 expression, suggesting that DNA methylation (show HELLS Proteins) might play a role for permanent silencing of previously down-regulated genes.

  5. P450(AROM) is localized in the cytoplasm and only seldom present in the fine extensions of the cells in frontal cortex.

  6. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1, HSD3B1 (show HSD3B1 Proteins), and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

  7. DNA methylation (show HELLS Proteins) may have a role in the permanent shutdown of promoter 2-directed cytochrome P450 19A1(CYP19A1) expression in large (granulosa derived) lutein cells

  8. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

  9. granulosa cell clustering is accompanied by marked increases in FSHr (show FSHR Proteins), IGF-1r (show IGF1R Proteins), and p450 arom expression, and precedes induction and subsequent peak E2 production

  10. demonstrates that cattle and sheep use different promoters to direct aromatase(Cyp19) expression during pregnancy

Mouse (Murine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. Findings indicate that sex chromosome factors determine sex differences in aromatase expression in the stria terminalis and in the anterior amygdaloid area of mouse embryos.

  2. CELF1 (show CELF1 Proteins) downregulates Cyp19a1 (Aromatase) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.

  3. Aromatase plays an important role in the survival of metastatic ERalpha (show ESR1 Proteins) breast cancer cells by suppressing anoikis.

  4. aromatase may play a key role in the pathogenesis of Sjogren syndrome-like lesions by controlling the target organ and adipose tissue-associated macrophage; increased MPC1 (show BRP44L Proteins) protein expression has a role in adiposity

  5. The protective effect of female gender on abdominal aortic aneurysms is due to estrogen synthesis and requires the presence of both ovarian and extragonadal/peripheral aromatase.

  6. Aromatase signaling is common in the mouse brain; locally synthesized brain estrogens could mediate biological effects by activating pre- and post-synaptic estrogen alpha and beta receptors, and androgen receptors.

  7. Male Aromatase knockout mice develop hepatic glucose intolerance.

  8. Cerebrovascular endothelial aromatase plays an important and sexually dimorphic role in cerebrovascular function and that aromatase inhibitors in clinical use may have cardiovascular consequences in both males and females.

  9. CYP19A1 gene is driven by promoters PII, I.4, and I.3 in the seminal vesicles, and by promoters PII and I.4 in the urinary bladder.

  10. Lhx2 (show LHX2 Proteins) is involved in the transcriptional regulation of aromatase in the rodent brain.

Horse (Equine) Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. co-localization of estrogen receotirs with aromatase in horse trophoblast suggests auto- or intracrine functions of oestrogens in this cell type

Goat Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. These data suggest that a major reason why CYP19A1 is not expressed in luteinized cells (and the corpus luteum) of ruminants may be the stimulatory effect of FOXL2 (show FOXL2 Proteins), which does not appear to be the case in the human and rat.

  2. Relative mRNA expression for insulin (show INS Proteins) and FSH (show BRD2 Proteins) receptors and cytochrome P450 aromatase in cultured follicles.

Xenopus laevis Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) interaction partners

  1. We found that cyp19a1 expression is highly regionalized in the brains of both sexes.

  2. Cyp19a1 expression leads to female sex determination in Xenopus laevis.

  3. brain-specific (show CALY Proteins) promoter/exon I.f of the cyp19a1 has cis (show CISH Proteins)-elements for several transcriptional factors

  4. binding sequences to a specific trans-activating factor upstream of the p450 (show POR Proteins) aromatase promoter II

  5. The ontogenetic patterns of Aro, Srd5a1 (show SRD5A1 Proteins) and Srd5a2 (show SRD5A2 Proteins) suggest that these genes are involved in sexual differentiation of gonads and brain already in early developmental stages.

Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) Protein Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity\; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.

Gene names and symbols associated with CYP19A1

  • aromatase (SAV_2383)
  • cytochrome P450 aromatase (pfcyp19b-tstr)
  • cytochrome P450 19A1 (CYP19A1)
  • cytochrome P450 19A3 (CYP19A3)
  • cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19 (CYP19)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1)
  • cytochrome P450, family 19, subfamily a, polypeptide 1 (Cyp19a1)
  • cytochrome P450, family 19, subfamily A, polypeptide 1 (cyp19a1)
  • Ar protein
  • ArKO protein
  • aro protein
  • ARO1 protein
  • Aromatase protein
  • CPV1 protein
  • CYAR protein
  • cyp19 protein
  • cyp19a protein
  • CYP19A1 protein
  • CYP19P1 protein
  • CYPXIX protein
  • Int-5 protein
  • Int5 protein
  • P-450AROM protein
  • P450 arom protein
  • P450AROM protein
  • p450arom-A protein

Protein level used designations for CYP19A1

aromatase , cytochrome P450 aromatase , CYPXIXA1 , cytochrome P-450AROM , cytochrome P450 19 type I , cytochrome P450, family19, subfamily A, polypeptide 1 , estrogen synthase , CYPXIXA3 , aromatase cytochrome P450 , cytochrome P450 19 type III , cytochrome P450, family 19, subfamily A, polypeptide 3 , type I cytochrome p450 aromatase , CYPXIX , cytochrome P450 19A1 , estrogen synthetase , cytochrome P450, subfamily XIX (aromatization of androgens) , flavoprotein-linked monooxygenase , microsomal monooxygenase , Cytochrome P450, 19, aromatase , P-450AROM , cytochrome P450 family 19 subfamily a , cytochrome P450, subfamily 19 , cytochrome P450, family XIX (conversion of androgen to estrogen), aromatase , cytochrome P450, 19, aromatase , cytochrome P450 17-alpha , Cytochrome P-450AROM , Cytochrome P450 19A1 , Estrogen synthase , p450 aromatase A

GENE ID SPECIES
1213743 Streptomyces avermitilis MA-4680
100379639 Takifugu rubripes
403331 Sus scrofa
403333 Sus scrofa
494003 Canis lupus familiaris
100144423 Ovis aries
414854 Gallus gallus
1588 Homo sapiens
25147 Rattus norvegicus
281740 Bos taurus
13075 Mus musculus
100009712 Equus caballus
100328545 Oryctolagus cuniculus
100861413 Capra hircus
373656 Xenopus laevis
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