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anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antibodies

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. Additionally we are shipping DDX58 Kits (18) and DDX58 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DDX58 23586 O95786
DDX58 230073 Q6Q899
DDX58 297989  
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Top anti-DDX58 Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DDX58 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 24-hour post infection immunoblots of whole cell lysates from primary murine microglia cells (2x106) untreated (0) or exposed to vesicular stomatitis virus at a range of viral particle/cell ratios. Data courtesy of Dr. Samantha Furr, University of North Carolina at Charlotte. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of RIG-1 in human heart tissue with this product at 5 μg/ml. Western blot analysis of RIG-1 in C2C12 cell lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IP, IHC, WB Western blot analysis of human RIG-I in HeLa cells by using RIG-I, mAb (Alme-1) .  Method: Cell extracts from HeLa cells either unstimulated (lane 1) or stimulated for 6h (lane 2), 16h (lane 3) or 24 h (lane 4) with Interferon γ were resolved by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with the RIG-I , mAb (Alme-1) at a 1:1000 dilution for 1 hour. Proteins were visualized using a peroxidase-conjugated polyclonal antibody to mouse IgG and a chemiluminescence detection system. Immunohistochemical staining of endogenous human RIG-I in different human tissues (paraffin sections) using anti-RIG-I, mAb (Alme-1) . Different human normal tissues (A: Nasopharynx; B: Colon; C: Endometrium) or cancer tissues (D: Breast; E: Skin; F: Ovarian) were stained with anti-RIG-I, mAb (Alme-1) by standard immunohistochemistry. 100 μg Log in to see 5 to 8 Days
$446.25
Details
Human Rabbit Un-conjugated WB Western blot analysis of DDX58 (ABIN388603) in 293 cell line lysates (35 µg/lane). DDX58 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$493.17
Details
Human Mouse Un-conjugated FACS 100 μg Log in to see 10 to 12 Days
$266.33
Details
Human Rabbit Un-conjugated IF, IHC, WB 100 μL Log in to see 14 Days
$369.79
Details

DDX58 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-DDX58 Antibodies

  1. Human Polyclonal DDX58 Primary Antibody for WB - ABIN388602 : Bao, Liu, Shan, Li, Garofalo, Casola: Human metapneumovirus glycoprotein G inhibits innate immune responses. in PLoS pathogens 2008 (PubMed)
    Show all 9 references for ABIN388602

  2. Human Monoclonal DDX58 Primary Antibody for FACS - ABIN2664928 : Kolakofsky, Kowalinski, Cusack: A structure-based model of RIG-I activation. in RNA (New York, N.Y.) 2012 (PubMed)
    Show all 6 references for ABIN2664928

  3. Human Polyclonal DDX58 Primary Antibody for EIA, WB - ABIN357193 : Li, Chen, Kato, Gale, Lemon: Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for ABIN357193

  4. Human Polyclonal DDX58 Primary Antibody for EIA, WB - ABIN357195 : Breiman, Grandvaux, Lin, Ottone, Akira, Yoneyama, Fujita, Hiscott, Meurs: Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon. in Journal of virology 2005 (PubMed)
    Show all 5 references for ABIN357195

  5. Human Monoclonal DDX58 Primary Antibody for IP, IHC - ABIN1169336 : Gack, Nistal-Villán, Inn, García-Sastre, Jung: Phosphorylation-mediated negative regulation of RIG-I antiviral activity. in Journal of virology 2010 (PubMed)
    Show all 4 references for ABIN1169336

  6. Human Polyclonal DDX58 Primary Antibody for EIA, IHC (p) - ABIN500606 : Akira, Uematsu, Takeuchi: Pathogen recognition and innate immunity. in Cell 2006 (PubMed)

  7. Human Polyclonal DDX58 Primary Antibody for WB - ABIN2775222 : Miyazaki, Kanto, Inoue, Itose, Miyatake, Sakakibara, Yakushijin, Kakita, Hiramatsu, Takehara, Kasahara, Hayashi: Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I. in Journal of medical virology 2008 (PubMed)

More Antibodies against DDX58 Interaction Partners

Human DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. These findings collectively support the conclusion that IKK (show CHUK Antibodies) modulates innate immune signaling cascades via phosphorylating the RIG-I cytosolic sensor, providing a feedback regulatory mechanism.

  2. ATP hydrolysis displaces wild-type RIG-I from this self-RNA but not from 5' triphosphate dsRNA.

  3. that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the RIG-I in a p53 and NFkappaB dependent manner

  4. Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I) to the adaptor MAVS (show MAVS Antibodies) protein and thereby blocked antiviral signaling.

  5. Data show that microRNA-136 (miRNA-136) antagonized H5N1 influenza A virus replication, and as an interleukin 6 (IL-6 (show IL6 Antibodies)) repressor, simultaneously as an immune trigger of retinoic acid-inducible gene 1 (show RARRES3 Antibodies) (RIG-I) signaling.

  6. These results showed that mRNA levels of MDA5 (show IFIH1 Antibodies) and RIG-1 (show RARRES3 Antibodies) were significantly decreased and increased, respectively, in chronic hepatitis B patients when compared to healthy controls.

  7. Data suggest that ppp-RNA orchestrating retinoic acid-inducible gene-I protein (RIG-I) activation to 5'-triphosphate siRNA targeting VEGF (show VEGFA Antibodies) (ppp-VEGF (show VEGFA Antibodies)) could be strategy for cancer therapy.

  8. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  9. HDAC6 (show HDAC6 Antibodies) transiently bound to RIG-I and removed the lysine 909 acetylation in the presence of viral RNAs, promoting RIG-I sensing of viral RNAs.

  10. RIG-I uses its autoinhibitory CARD2 (show KRT8 Antibodies)-Hel2i (second CARD-helicase insertion domain) interface as a barrier to select against non-blunt ended double-stranded RNAs.

Mouse (Murine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation

  2. identifies DDX58 and MTHFSD as two TDP-43 (show TARDBP Antibodies) targets that are misregulated in amyotrophic lateral sclerosis. 1

  3. Data show that preconditioning with poly(I:C) alters toll (show TLR4 Antibodies)-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions.

  4. Cytosolic LMW FGF2 (show FGF2 Antibodies) functions as a negative regulator in RIG-I-mediated antiviral signaling.

  5. results indicate that Lyn (show LYN Antibodies) plays a positive regulatory role in RIG-I-mediated interferon (show IFNA Antibodies) expression as a downstream component of IPS-1 (show ISYNA1 Antibodies)

  6. In lung epithelial cells, retinoic acid-inducible gene-1 (show RARRES3 Antibodies) (RIG-I) was identified as the major RIG-I-like receptor required for RSV-induced protease expression via MAVS (show MAVS Antibodies).

  7. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response

  8. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity.

  9. senses hepatitis B virus RNA, and counteracts HBV polymerase

  10. RIG-I-like receptor (RLR (show DHX58 Antibodies)) signaling pathway was significantly affected by Yersinia pestis infection

Pig (Porcine) DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) interaction partners

  1. Viral RNA polymerase components PB2, PB1, and PA directly target RIG-I.

  2. These data indicate that classical swine fever virus can be recognized by both RIG-I and MDA5 (show IFIH1 Antibodies) to initiate the RIG-I signaling pathway to trigger innate defenses against infection.

  3. DDX58 had two nonsynonymous SNPs in the helicase (show DNA2 Antibodies) domain.

DDX58 Antigen Profile

Protein Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Gene names and symbols associated with DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58) antibody
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (Ddx58) antibody
  • 6430573D20Rik antibody
  • C330021E21 antibody
  • RHIV-1 antibody
  • RIG-1 antibody
  • RIG-I antibody
  • RIGI antibody
  • RLR-1 antibody

Protein level used designations for DDX58

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I , probable ATP-dependent RNA helicase DDX58 , putative ATP-dependent RNA helicase DDX58 , retinoic acid-inducible protein I , DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 , probable ATP-dependent RNA helicase DDX58-like , DEAD box protein 58 , DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide , RIG-1 , RIG-I-like receptor 1 , RNA helicase RIG-I , retinoic acid inducible gene I , retinoic acid-inducible gene 1 protein , retinoic acid-inducible gene I protein , DEAD-box protein 58 , DEAD/H box polypeptide RIG-I , retinoic acid-inducible gene-I , RNA helicase induced by virus

GENE ID SPECIES
465035 Pan troglodytes
704638 Macaca mulatta
100067920 Equus caballus
100347707 Oryctolagus cuniculus
100408692 Callithrix jacchus
100443290 Pongo abelii
23586 Homo sapiens
230073 Mus musculus
297989 Rattus norvegicus
100686785 Canis lupus familiaris
396723 Sus scrofa
504760 Bos taurus
101107257 Ovis aries
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