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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Additionally we are shipping DDX41 Antibodies (72) and DDX41 Proteins (5) and many more products for this protein.
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DDX41 mutations lead to development of high-risk myelodysplastic syndrome.(review)
An increasing number of both inherited and acquired mutations in DDX41 gene are identified from myelodysplastic syndrome and/or acute myeloid leukemia (show BCL11A ELISA Kits) (MDS (show PAFAH1B1 ELISA Kits)/AML (show RUNX1 ELISA Kits)) patients.
data demonstrate that DDX41 suppresses p21 (show CDKN1A ELISA Kits) translation without disturbing the function of p53 (show TP53 ELISA Kits) to directly induce p21 (show CDKN1A ELISA Kits) mRNA expression, this process indirectly requires p53 (show TP53 ELISA Kits), perhaps in the form of another p53 (show TP53 ELISA Kits) target gene or as a still undefined posttranscriptional function of p53 (show TP53 ELISA Kits).
This study uncovered a pathogenic role of p.R525H DDX41 in the slow growth rate of tumor cells. Age-dependent epigenetic alterations or other somatic changes might collaborate with the mutation to cause AML (show RUNX1 ELISA Kits).
This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations.
corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
results suggest a mechanism whereby c-di-GMP (show NT5C2 ELISA Kits) and c-di-AMP (show APRT ELISA Kits) are detected by DDX41, which forms a complex with STING to signal to TBK1 (show TBK1 ELISA Kits)-IRF3 (show IRF3 ELISA Kits) and activate the interferon (show IFNA ELISA Kits) response
DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 (show SNX2 ELISA Kits) suggesting that PX domains may also participate in protein-protein interaction.
Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK (show BTK ELISA Kits) phosphorylation site.
TRIM21 (show TRIM21 ELISA Kits) is an interferon (show IFNA ELISA Kits)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
, DEAD-box protein abstrakt
, probable ATP-dependent RNA helicase DDX41-like
, DEAD box protein 41
, DEAD box protein abstrakt homolog
, probable ATP-dependent RNA helicase DDX41
, putative RNA helicase