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DNA (Cytosine-5-)-Methyltransferase 3 beta Proteins (DNMT3B)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3B Antibodies (92) and DNMT3B Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT3B 1789 Q9UBC3
Rat DNMT3B DNMT3B 444985  
DNMT3B 13436 O88509
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Top DNMT3B Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$365.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DNMT3B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) Interaction Partners

Zebrafish DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. dnmt7 specifically methylates no tail gene in the genome

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.

Human DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses.

  2. The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A (show DNMT3A Proteins)/3B, downregulated the expression of SOCS1 (show SOCS1 Proteins) and increased SOCS1 (show SOCS1 Proteins) gene promoter CpG island methylation.

  3. Our results demonstrate DNMT3B4-del as a critical factor in developing aberrant DNA methylation (show HELLS Proteins) patterns during lung tumorigenesis and suggest that DNMT3B4-del may be a target for lung cancer prevention.

  4. Results suggested that the DNMT3B -149C/T polymorphism is associated with a genetic susceptibility for developing LSCC in a Chinese population.

  5. Data indicate an epigenetic prognostic signature in glioblastomas based on expression of polycomb (show CBX2 Proteins) repressive complex 2 (EZH2 (show EZH2 Proteins)), DNA-methyltransferases DNMT1 (show DNMT1 Proteins) and 3B which can be used easily in routine neuropathology practice.

  6. miR (show MLXIP Proteins)-124 and miR (show MLXIP Proteins)-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B and DNMT1 (show DNMT1 Proteins) in colorectal carcinoma.

  7. Increasing DNA methylation (show HELLS Proteins) in the gene-coding area of DNMT3B was associated with higher risk of colorectal adenomas (OR = 1.34; 95% CI: 1.01-1.79 per SD).

  8. To correlate DNMTs expression with DNA methylation (show HELLS Proteins), DNMT1 (show DNMT1 Proteins), DNMT3A (show DNMT3A Proteins) and DNMT3B mRNA levels in 5 colorectal cancer cell lines; results suggest that cellular DNMT (show DNMT1 Proteins) expression is positively correlated with global DNA methylation (show HELLS Proteins) level but not with regional DNA hypermethylation at each locus.

  9. Deregulated Dnmt3b targets have prognostic impact in acute myeloid leukemia patients.

  10. DNMT1 (show DNMT1 Proteins), DNMT3B, and EZH2 (show EZH2 Proteins) were expressed at significantly higher levels in tumor vs. normal tissues.

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. The epiblast expressed epithelial markers, MUC1 (show MUC1 Proteins) and E-CADHERIN (show CDH1 Proteins), and the pluripotency markers, DNMT3B and CRIPTO (show TDGF1 Proteins).

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.

  2. The expression levels of DNMT3a (show DNMT3A Proteins) and DNMT3b were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) interaction partners

  1. Downregulation of DNMT3B, one of the targets identified using this method, radiosensitizes cancer cells by disturbing multiple DNA damage responses.

  2. High levels of Dnmt3b expression prolong leukemia latency.

  3. The expression of DNMT1 and DNMT3b was decreased at 1 mT, and 50 Hz ELF-EMF can increase the expression...the alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF-EMF exposure

  4. DKO cardiomyocytes showed virtual absence of targeted Dnmt3a (show DNMT3A Proteins) and Dnmt3b mRNA transcripts.

  5. An unexpected oncogenic role for Dnmt3a (show DNMT3A Proteins) in MTCL through methylation-independent repression of Dnmt3b.

  6. we report that cardiac specific deletion of Dnmt3b, the predominant DNA methyltransferase (show DNMT1 Proteins) in adult mouse hearts, leads to an accelerated progression to severe systolic insufficiency and myocardial thinning without a preceding hypertrophic response.

  7. These results indicated a role for the miR29b-Dnmt3a (show DNMT3A Proteins)/3b-DNA methylation (show HELLS Proteins) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development

  8. data suggest that Dnmt3a (show DNMT3A Proteins) and Dnmt3b are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development

  9. Study reveals that the DNMT3 de novo methyltransferases DNMT3A (show DNMT3A Proteins) and DNMT3B play both redundant and specific functions in the establishment of DNA methylation (show HELLS Proteins) in the mouse embryo.

  10. Dnmt3b-deficient cells can contribute to the male and female germ-lines in chimeric mice and can produce normal progeny, establishing that Dnmt3b is dispensable for mouse gametogenesis and imprinting.

DNMT3B Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Gene names and symbols associated with DNMT3B

  • DNA (cytosine-5-)-methyltransferase 4 (dnmt4)
  • DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B)
  • DNA (cytosine-5-)-methyltransferase 3 beta (LOC100218113)
  • DNA methyltransferase 3B (dnmt3b)
  • DNA (cytosine-5-)-methyltransferase 3 beta (dnmt3b)
  • DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b)
  • DNA methyltransferase 3B (Dnmt3b)
  • cb91 protein
  • cb633 protein
  • DNMT3B protein
  • dnmt3bl protein
  • dnmt7 protein
  • ICF protein
  • ICF1 protein
  • LOC100218113 protein
  • M.HsaIIIB protein
  • MmuIIIB protein
  • sb:cb91 protein
  • wu:fb16h07 protein

Protein level used designations for DNMT3B

DNA (cytosine-5)-methyltransferase 3B , DNA (cytosine-5-)-methyltransferase 3 beta , DNA cytosine-5 methyltransferase 3 beta , DNA (cytosine-5)-methyltransferase 3B-like , DNA methyl transferase beta , DNA methyltransferase 3B , DNA MTase HsaIIIB , DNA methyltransferase HsaIIIB , DNA (cytosine-5-)-methyltransferase 3 beta, like , DNA (cytosine-5-)-methyltransferase 7 , fb16h07 , DNA MTase MmuIIIB , DNA methyltransferase MmuIIIB

GENE ID SPECIES
317744 Danio rerio
458174 Pan troglodytes
711553 Macaca mulatta
100053900 Equus caballus
100218113 Taeniopygia guttata
100412936 Callithrix jacchus
100459992 Pongo abelii
100466728 Ailuropoda melanoleuca
100500777 Ovis aries
100598378 Nomascus leucogenys
100528060 Anolis carolinensis
1789 Homo sapiens
321084 Danio rerio
419287 Gallus gallus
100302109 Sus scrofa
353354 Bos taurus
444985 Rattus norvegicus
13436 Mus musculus
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