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DRAM1 is regulated as part of the p53 tumor suppressor pathway. Additionally we are shipping DNA-Damage Regulated Autophagy Modulator 1 Kits (3) and and many more products for this protein.
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Human Polyclonal DRAM1 Primary Antibody for IHC, WB - ABIN350294
Crighton, Wilkinson, OPrey, Syed, Smith, Harrison, Gasco, Garrone, Crook, Ryan: DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. in Cell 2006
Show all 3 references for ABIN350294
Mouse (Murine) Polyclonal DRAM1 Primary Antibody for IHC, WB - ABIN350296
Carninci, Kasukawa, Katayama, Gough, Frith, Maeda, Oyama, Ravasi, Lenhard, Wells, Kodzius, Shimokawa, Bajic, Brenner, Batalov, Forrest, Zavolan, Davis, Wilming, Aidinis, Allen, Ambesi-Impiombato et al.: The transcriptional landscape of the mammalian genome. ... in Science (New York, N.Y.) 2005
DRAM1 regulates apoptosis by inhibiting BAX (show BAX Antibodies) degradation.
DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide.
Suggest that promoting DRAM-mediated autophagy together with PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) inhibition might be more effective for autophagy-based therapy in hepatoma.
DRAM is an important gene for the enhancement of p53 (show TP53 Antibodies)-dependent apoptosis.
DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes.
DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species
DRAM triggers lysosomal membrane permeabilization and cell death in CD4 (show CD4 Antibodies)(+) T cells infected with HIV.
these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells.
Overexpression of miR (show MLXIP Antibodies)-199a-5p inhibits DRAM1 and Beclin1 (show BECN1 Antibodies) expression.
p73 (show TP73 Antibodies)-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia (show PML Antibodies) cells.
DRAM1 knockdown aggravates OGD (show FGFR1 Antibodies)/R-induced cell injury.
DRAM-1 encodes not just one mRNA, but a series of p53 (show TP53 Antibodies)-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
DNA-damage regulated autophagy modulator 1
, DNA damage-regulated autophagy modulator protein 1
, damage-regulated autophagy modulator
, Damage-regulated autophagy modulator