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Death Effector Domain Containing Proteins (DEDD)

DEDD encodes a protein that contains a death effector domain (DED). Additionally we are shipping DEDD Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DEDD 9191 O75618
DEDD 21945 Q9Z1L3
Rat DEDD DEDD 83631 Q9Z2K0
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Top DEDD Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days

DEDD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Top referenced DEDD Proteins

  1. Human DEDD Protein expressed in Escherichia coli (E. coli) - ABIN1098762 : Schickling, Stegh, Byrd, Peter: Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. in Cell death and differentiation 2001 (PubMed)
    Show all 2 references for ABIN1098762

More Proteins for Death Effector Domain Containing (DEDD) Interaction Partners

Human Death Effector Domain Containing (DEDD) interaction partners

  1. DEDD protein role in cell proliferation and migration of bladder cancer

  2. Via direct interaction with the class III PI-3 (show PI3 Proteins)-kinase (PI3KC3)/Beclin1 (show BECN1 Proteins), DEDD activated autophagy and induced the degradation of Snail (show SNAI1 Proteins) and Twist, two master regulators of EMT (show ITK Proteins)

  3. FAS (show FAS Proteins)-associated death domain (FADD (show FADD Proteins))-DED (show AATF Proteins)-induced reactive oxygen species (ROS (show ROS1 Proteins)) generation is triggered by membrane localization of FADD (show FADD Proteins)-DED (show AATF Proteins), which shifts the cells into a state that stimulates and fuels ROS (show ROS1 Proteins) and ultimately results in cell death.

  4. DEDD forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC

  5. DEDD and DEDD2 (show DEDD2 Proteins) may be important mediators for death receptors and that they may target caspases to the nucleus.

Mouse (Murine) Death Effector Domain Containing (DEDD) interaction partners

  1. In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation.

  2. DEDD plays an important role in maintenance of the Akt (show AKT1 Proteins) protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues.

  3. DEDD acts as a novel inhibitor of the mitotic Cdk1 (show CDK1 Proteins)/cyclin B1 (show CCNB1 Proteins) complex and is an impeder of cell mitosis, and its absence critically influences cell and body size via modulation of rRNA synthesis

  4. The death effector domain-containing DEDD supports S6K1 (show RPS6KB1 Proteins) activity via preventing Cdk1 (show CDK1 Proteins)-dependent inhibitory phosphorylation.

DEDD Protein Profile

Protein Summary

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with DEDD

  • death effector domain containing (DEDD)
  • death effector domain-containing (Dedd)
  • CASP8IP1 protein
  • DEDD1 protein
  • Dedpro1 protein
  • Deft protein
  • FLDED1 protein
  • KE05 protein

Protein level used designations for DEDD

DEDPro1 , FLDED-1 , death effector domain-containing protein , death effector domain-containing testicular molecule , tumor necrosis factor (ligand) superfamily, member 19

9191 Homo sapiens
21945 Mus musculus
83631 Rattus norvegicus
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